Computational analyses of transcriptome regulation on RNA level

我的生物信息学小组研究生物体的转录组，如人类，以及它是如何调节的。转录组对应于在给定细胞中被激活的一组基因。它由所谓的转录物，线性RNA分子组成，这些分子要么编码蛋白质产物，要么作为所谓的RNA基因发挥作用。这两类分子，即蛋白质和RNA基因，是决定细胞状态的关键。与蛋白质及其相互作用相反，人们对转录组及其调控方式知之甚少。

My Bioinformatics group investigates the transcriptome of organisms such as the human, and how it is regulated. The transcriptome corresponds to the set of genes that are activated in a given cell. It consists of so-called transcripts, linear RNA molecules that either encode a protein product or function as so-called RNA genes. Both classes of molecules, i.e. proteins and RNA genes, are key to determining the state of a cell. In contrast to proteins and their interactions, comparatively little is known about the transcriptome and how it is regulated.