Biophysical basis of single cell force spectroscopy

生物过程，如胚胎发生、器官发育、细胞通讯、免疫反应和大量的宿主-病原体相互作用，在一定程度上由相互作用的实体之间的粘附力定义，这一领域对所有选定的生物物理学家来说都是陌生的。这种粘附性相互作用也应该在医疗干预中发挥关键作用，包括运送微粒药物方案和假体植入物。另一个例子是吸入颗粒物。为了对健康产生不利影响，他们需要坚持空气-肺界面。探索生物学这一整体方面的方法将使现代生物学研究和医学干预发生革命性变化。

Biological processes such as embryogenesis, organ development, cellular communication, immune response, and a large spectrum of host-pathogen interactions are at some level defined by adhesion forces between interacting entities, an area foreign to all but few selected biophysicists. Such adhesive interaction should also play a crucial role in medical interventions, including delivery of particulate drug regimens and prosthetic implant. Another example is inhaled particles. To have adverse health effect, they need to adhere to the air-lung interface. A method to explore this integral aspect of biology will revolutionize modern biological research and medical intervention.