Novel monomer and polymer synthesis with antimicrobial function and their reaction with enzymes

获得性细菌感染影响所有住院患者的近5%，并通过医疗设备传播。细菌能够附着在用于制造这种装置的生物材料上，并促进生物膜的形成。这是一个持续的挑战，因为传统的抗生素系统治疗往往不足以克服细菌生物膜的复杂组织。随着加拿大和其他国家日益老龄化的人口，需要具有益生菌和/或微生物抗性功能的聚合物生物材料，在某些情况下还具有愈合特性，以更好地应对微生物挑战。这项资助的假设是，从合成途径产生的含有抗菌剂的单体和抗细菌单体及其聚合物将产生功能生物材料。主要有三个目标：1)研究实验室以前生产的新型氨基甲酸酯氟化物单体对唾液衍生酶的抵抗力，并用这些单体制备针对物理性能和耐酶/细菌相互作用进行优化的聚合物。2)将化学结合到新型抗菌单体中，以产生具有实际物理性能和抗细菌生物膜形成的聚合物。3)使用合成的可降解水凝胶材料生成新的牙周组织以修复牙齿周围的组织，该材料促进宿主成纤维细胞的结缔组织和宿主内皮细胞的新血管的生长。上述三个目标的发现将结合在一起，产生创新的新化学，并更好地了解单体化学结构对生物材料的物理、生化和生物结果的影响，用于含有环境的细菌对与加拿大医疗保健行业相关的产品实现成功的临床/商业影响的重大挑战。这项研究是在生物医学工程领域(一个就业增长率为72%的领域-美国劳工统计局)培训HQP。

Acquired bacterial infections affect nearly 5% of all hospitalized patients and are transmitted via medical devices. Bacteria have the ability to adhere to biomaterials used to fabricate such devices and promote the formation of biofilms. This is an on-going challenge as traditional systematic treatment by antibiotics is often insufficient to overcome the complex organization of the bacterial biofilms. With an increasing aging population in Canada and other countries, the need for polymeric biomaterials with pro-biotic and/or microbial resistant function along with healing character in some instances, is needed to better address microbial challenges. The hypothesis of this grant is that antimicrobial containing monomers and bacterial resistant monomers, and their polymers, generated from synthetic pathways will yield functional biomaterials. There are three principal objectives: 1) To study the resistance of novel urethane-fluorinated monomers generated previously in the laboratory to saliva derived enzymes, and to produce polymers with these monomers, that are optimized for physical performance properties, and resistance to enzyme/bacterial interactions. 2) To incorporate chemistry into novel antimicrobial monomers that will yield polymers with practical physical properties and resistance to bacterial biofilm formation. 3) To generate new periodontal tissues to repair tissue around teeth using a synthetic degradable hydrogel material which facilitates the growth of connective tissue from the host fibroblast cells, and new blood vessels from the host endothelial cells. The findings from all 3 of the above objectives will combine to yield innovative new chemistries and a greater understanding of the influence of monomer chemical structure on the physical, biochemical and biological outcomes of biomaterials, conceived for use where bacteria containing environments yield significant challenges towards achieving a successful clinical/commercial impact for products associated with Canada's healthcare industry. This research is training HQP in the biomedical engineering field (a field with 72% job growth rate- US Bureau of labor statistics).