Post-transcriptional regulation of gene expression in S. cerevisiae

包括人类在内的所有多细胞生物体的生长和发育都需要体内的细胞具有特殊的功能。细胞特化涉及不同细胞类型中存在不同的蛋白质，例如，肌肉细胞中的肌肉蛋白质和肝细胞中的肝脏蛋白质。细胞通过在称为翻译的过程中使用被称为mRNAs的特定信号来产生单独的蛋白质。我们正在研究两种控制细胞中存在的蛋白质的机制：翻译调节和信使核糖核酸降解。翻译调控涉及的机制可以开启或关闭特定mRNAs的翻译，从而控制相应蛋白质的产生。信使核糖核酸的降解会破坏相应的信使核糖核酸，从而阻止蛋白质的产生。

The growth and development of all multi-celled organisms, including humans, requires cells within the body to adopt specialized functions. Cell specialization involves the presence of different proteins in different cell types, for example, muscle proteins in muscle cells and liver proteins in liver cells. Cells produce individual proteins by using specific signals known as mRNAs in a process called translation. We are studying two mechanisms that control what proteins are present in cells: translational regulation and mRNA degradation. Translational regulation involves mechanisms can turn on or off the translation of specific mRNAs, thereby controlling the production of the corresponding protein. mRNA degradation blocks the production of a protein by destroying the corresponding mRNA.