Transport, bioavailability and bioaccessibility of contaminants in the changing North

气候变化、新的北部采矿项目和新兴亚洲经济体增加的大气沉积将改变加拿大北部金属（矿物）的运输、转化和命运，对生态系统健康产生未知的后果。我提出了一个极地计划，该计划将调查可能影响北方三种主要污染物（汞、砷和硒）的移动性、反应性和对高等生物的可用性的关键转变，这三种元素具有已知的生物相互作用。金属（类）s循环中选定的生物地球化学转化将在一个日益重要但鲜为人知的变化的北方特征中进行研究，即从永久冻土中吸收旧碳的融化池塘。此外，将与北方人协商，通过体外消化研究这些元素在不同制备技术的传统食品中的生物可及性。该研究将培养15名hqp，其中包括3名北方人。我建议与社区、猎人和猎人组织以及高中开展广泛的互动、交流、培训和分享传统知识的项目。该计划将在北部的5个地点进行。这笔拨款是我从蒙特利尔到北方的交通以及在Kuujjuarapik、Bylot、Pond Inlet和Yellowknife的住宿的唯一资金来源，因此它对这项研究计划至关重要。在过去的6年里，我发表了37篇科学论文和5本书章节，培训了41个人。我的综合培训计划包括在国内和国际实验室的合作和实习，以及我对学生的密切监督（包括密集的写作研讨会，使毕业生的工作效率很高）。我有16年的北方研究经验，我有信心高效、及时地完成目标，为加拿大的科学和政策做出切实的原创性贡献。随着气候变化、采矿活动和大气沉积之间的相互作用日益增加，该项目将满足人们对更好地了解北方主要北极污染物的命运和暴露的预期变化的迫切需要。

Climate change, new northern mining projects and increased atmospheric deposition from emerging Asian economies will modify the transport, transformation an fate of metal(oid)s in northern Canada, with unknown consequences on ecosystem health. I propose a polar program that will investigate key transformations that may affect the mobility, reactivity and availability to higher organisms of three key northern contaminants, mercury, arsenic and selenium, three elements with known biological interactions. Selected biogeochemical transformations in the cycling of metal(oid)s will be studied in an increasingly important and poorly known feature of the changing North, thaw ponds receiving old carbon from permafrost. Further, biochemical studies on the bioaccessibility of these elements in traditional food undergoing different preparation techniques will be studies by in vitro digestion, in consultation with northerners. This research will train 15 HQPs including 3 northerners. I propose an extensive program of interaction, communication, training and sharing of traditional knowledge with communities, hunters and trappers organizations and high schools. The program will be conducted at 5 northern locations. This grant is my only source of funding for transportation from Montreal to the North and for accomodations at Kuujjuarapik, Bylot, Pond Inlet, and Yellowknife, and it is therefore of vital importance for this research initiative. I have been very productive, with 37 scientific articles and 5 book chapters published in the last 6 years, and 41 persons trained. My comprehensive training program includes collaborations and internships in national and international labs, and close student supervision by me (including intensive writing workshops leading to high productivity by graduates). I have 16 years of experience in northern research, and I am confident to meet the objectives in an efficient and timely manner, with tangible original contributions to science and policy in Canada. With increasing interactions between climate change, mining activities and atmospheric deposition, this program will answer an urgent need for a better understanding of the anticipated changes in the fate of and exposure to key arctic contaminants in the North.