"Static, dynamic and surface characterization of bio and engineering materials"

背景：随着微型器件在通信、汽车和电子领域的广泛应用， 在生物医学工业中，这些器件的静态和动态特性对于有效的设计和进一步的开发起着重要的作用。虽然微型器件的全面表征是用频闪干涉测量法进行的，但生物成像和其他材料无损检测现在是用低相干干涉测量法进行的。LCI的一个成功应用是光学相干断层扫描（OCT），它是在20世纪90年代初发明的一种高分辨率非侵入性和非接触式生物医学成像。 拟议研究：拟议的研究计划的总体目标是利用光学干涉测量法对微器件进行静态，动态和表面表征，并对生物和其他工程材料的非视觉缺陷进行非破坏性评估。在拟议的研究中，声光调制频闪干涉仪，连同相移的非机械手段将被开发，使瞬时相移这样的表征。由于所需的相位是即时捕获的，因此相机可以定时以定期捕获多个图像。这消除了对特定电子控制装置的需要，使测量过程更简单。在生物成像和工程材料的无损检测中，将开发一种基于线场反射光学的低相干干涉仪，以提高速度并减小由于透镜像差和扫描畸变引起的误差。 潜在影响：该项目的潜在影响可以在与航空航天，微电子和生物医学行业相关的材料表征和无损检测应用中感受到;和生物成像。拟议的LCI与频闪干涉测量一起将提供成功构建新型频闪低相干干涉仪的平台，用于瞬态生物过程的体内成像，其中运动伪影一直是一个重大挑战。

Background: With numerous applications for microdevices in communication, automotive, and biomedical industries, static and dynamic characterization of these devices play significant role for effective design and further development. While comprehensive characterization of microdevices is performed with stroboscopic interferometry, bioimaging and other material NDT are now performed by Low Coherence Interferometry. One successful application of LCI is Optical Coherence Tomography (OCT), invented in early 1990s as a high resolution noninvasive and non-contact biomedical imaging. Proposed Research: The overall aim of the proposed research program is to exploit optical interferometry for static, dynamic and surface characterization of microdevices and to non-destructively evaluate bio and other engineering materials for non-visual defects. In the proposed research, an acousto optic modulated stroboscopic interferometer, together with a non-mechanical means of phase shifting will be developed to enable instantaneous phase shifting for such characterization. Since the required phases are captured instantaneously, the cameras can be timed to capture multiple images at regular intervals. This eliminates the need for a specific electronic control device, making the measurement process simpler. For bioimaging and NDT of engineering materials, a line field reflective optics based low coherence interferometer will be developed to increase speed and reduce the errors due to lens aberration and scanning distortion. Potential impact: The potential impact of the project can be felt in applications related to aerospace, microelectronic, and biomedical industries in Material Characterization and NDT; and Bioimaging. The proposed LCI together with stroboscopic interferometry will provide the platform for successful building of a novel stroboscopic low coherence interferometer for in-vivo imaging of transient biological processes where motion artifacts have been a significant challenge.