Regulation of membrane trafficking by the PACS family of proteins

蛋白质在各种细胞隔间的正确运动对细胞的正常功能至关重要。我们研究了一系列名为磷酸尿苷酸性簇分类蛋白(PACS-1和2)的蛋白质，它们与大量客户蛋白特异性地相互作用，并将它们运输到精确的细胞位置，以调节特定的细胞功能，如调节细胞死亡。目前尚不清楚PACS如何与众多的细胞伙伴相互作用并产生不同的影响。我们的工作将致力于破译PACS蛋白及其客户蛋白上使这些相互作用成为可能的特定结构域。此外，我们将研究位于PACS蛋白中的特定信号，使它们能够定位到不同的细胞间隔。总之，这些研究将提高我们对基本原理的认识，确保蛋白质正确定位到不同的细胞隔间。

The correct movement of proteins in the various cellular compartments is vital to the proper function of a cell. We study a family of proteins called the Phosphofurin Acidic Cluster Sorting Proteins (PACS-1 and 2) that specifically interact with numerous client proteins and traffic them to precise cellular locations to regulate specific cellular functions such as the regulation of cell death. It remains unknown how PACS can interact with numerous cellular partners and exert different affects. Our work will aim to decipher specific domains on the PACS proteins and on their client proteins that enable these interactions. Furthermore, we will study specific signals located in the PACS proteins enabling their localization to different cellular compartments. Together, these studies will advance our knowledge of basic fundamental principles ensuring the proper localization of protein to various cellular compartments.