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Topical Granzyme B Inhibitors for Wound Healing and Scarring

Topical Granzyme B Inhibitors for Wound Healing and Scarring
用于伤口愈合和疤痕的外用颗粒酶 B 抑制剂
批准号:
324707
负责人:
Granville David J
金额:
$17.27万
依托单位国家:
加拿大
项目类别:
Operating Grants
财政年份:
2015
资助国家:
加拿大
项目状态:
已结题
起止时间:
2015-03-01 至 2018-03-01

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中文摘要
翻译
颗粒酶B(Granzyme B,Gzm B)是一种受紫外光诱导的蛋白质降解酶。当GzmB在皮肤中升高时,它会阻止皮肤自我修复,这可能导致疤痕。我们之前的工作,我们基因敲除GzmB,
英文摘要
Granzyme B (GzmB) is a protein-degrading enzyme that is induced by sunlight (UV). When GzmB is elevated in the skin, it prevents the skin from repairing itself and this can lead to scarring. Our previous work, in which we genetically knocked out GzmB, sho
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Novel mechanisms and therapeutic approach for aging-related pruritus
  • 批准号:
    461300
  • 项目类别:
    Operating Grants
  • 资助金额:
    $63.53万
  • 财政年份:
    2022
  • 负责人:
    Granville David J
  • 依托单位:
Prize 202203PJT - Novel mechanisms and therapeutic approach for aging-related pruritus
  • 批准号:
    467983
  • 项目类别:
    Operating Grants
  • 资助金额:
    $3.64万
  • 财政年份:
    2022
  • 负责人:
    Granville David J
  • 依托单位:
Granzymes in Tissue Injury, Inflammation and Repair
  • 批准号:
    312527
  • 项目类别:
    Operating Grants
  • 资助金额:
    $131.53万
  • 财政年份:
    2014
  • 负责人:
    Granville David J
  • 依托单位:
Topical Granzyme B Inhibitor Research and Development
  • 批准号:
    255345
  • 项目类别:
    Operating Grants
  • 资助金额:
    $34.37万
  • 财政年份:
    2012
  • 负责人:
    Granville David J
  • 依托单位:
海外基金