Enhancing the IMHRD cohort to support study of the exposome in autoimmune disease
加强 IMHRD 队列以支持自身免疫性疾病暴露组研究
基本信息
- 批准号:10871488
- 负责人:
- 金额:$ 41.53万
- 依托单位:
- 依托单位国家:美国
- 项目类别:
- 财政年份:2023
- 资助国家:美国
- 起止时间:2023-09-18 至 2025-08-31
- 项目状态:未结题
- 来源:
- 关键词:AddressAdvisory CommitteesAfrican AmericanAfrican American populationAfrican ancestryAutoimmuneAutoimmune DiseasesAwardBiologicalBiological MonitoringChemical ExposureChemicalsClinical ResearchCollaborationsCommunitiesComplexDataData ScienceDiagnosisDisease OutcomeElectronic Health RecordEnvironmentEnvironmental ExposureEnvironmental Risk FactorEpidemiologyEpigenetic ProcessExposure toFamilyFemaleFishesFundingGenesGeneticGoalsHealthImmune System DiseasesIslandLife Cycle StagesLinkLupusMahi-MahiMapsMeasuresMedicalMethodologyMolecularNational Institute of Arthritis, and Musculoskeletal, and Skin DiseasesNational Institute of Environmental Health SciencesNational Institute on Minority Health and Health DisparitiesNeighborhoodsOntologyOutcomeParticipantPatientsPatternPhenotypePoly-fluoroalkyl substancesPopulationPopulation DatabasePositioning AttributePrevalenceResearchResolutionResourcesRheumatismScienceSclerodermaSeaSelection CriteriaSeveritiesSiteSouth CarolinaStatistical Data InterpretationSystemic Lupus ErythematosusSystemic SclerodermaUnited States National Institutes of HealthUniversitiesclinical centercohortdemographicsdesignepigenomicsgenetic analysishealth disparityhigh dimensionalityhuman population geneticsimprove minority healthimprovedinnovationinterestmethod developmentnovelpopulation healthrecruitresponsesample collectionsocialstudy populationtool
项目摘要
ABSTRACT
Systemic sclerosis (SSc) and Systemic lupus erythematosus (SLE, or lupus) are autoimmune diseases with
disproportionate prevalence and severity burdens among females of African ancestry (AA). Several
environmental risk factors are suspected to play a role; however, relationships are complex and difficult to
assess, thus much remains unknown. It is clear there is a critical need to improve studies of environmental
exposure and autoimmune disease. In response, NIH has released a Notice of Special Interest entitled:
“EXposome in Autoimmune Disease Collaborating Teams PLANning Awards (EXACT-PLAN)” intended to
advance the study of the exposome in autoimmune diseases. This project is designed to contribute to this effort
by establishing collaborations, study populations, and analytic approaches required to better characterize and
assess holistic environmental exposures in health studies on autoimmune disease. We are well positioned to
achieve this goal, as we leverage resources within the NIAMS-funded Improving Minority Health in Rheumatic
Diseases (IMHRD) Core Center for Clinical Research at the Medical University of South Carolina (MUSC), which
focuses on two autoimmune diseases, systemic sclerosis (SSc) and systemic lupus erythematosus (SLE), will
be leveraged. In addition, we present a strong research team with expertise in exposure science, epidemiology,
human population genetics, social epigenomics, and clinical research necessary to improve exposome research
on autoimmune disease. The overarching objective of this project is to improve understanding of how
environmental exposures influence autoimmune disease. Goals are to develop resources needed to address the
exposome within our study populations, develop innovative methodologies that will improve exposome studies,
and to establish our research group as a major contributor to national research efforts centered on the exposome.
The motivating hypothesis is that variability in environmental exposure (across the life course) is associated with
worse autoimmune disease outcomes. The first specific aim focuses on establishing a cohort within the IMHRD
study population that will support comprehensive characterization of the exposome. This also includes
recruitment of 100 additional participants to enhance our existing study population specifically for exposome
research. The second aim will develop novel data science tools to enhance integration and analysis of genetic,
environmental, epigenetic, and social measures across the life course. Accomplishing these aims will establish
a unique, health disparity cohort with autoimmune disease tailored specifically for exposome research, contribute
findings that will improve understanding of complex links between the environment and autoimmune disease,
and provide novel data science tools that will improve methodologies for analysis of the exposome.
摘要
项目成果
期刊论文数量(0)
专著数量(0)
科研奖励数量(0)
会议论文数量(0)
专利数量(0)
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John Lanier Pearce其他文献
John Lanier Pearce的其他文献
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{{ truncateString('John Lanier Pearce', 18)}}的其他基金
Novel Approaches for Linking Air Quality Mixtures, Climate, and Human Health
将空气质量混合物、气候和人类健康联系起来的新方法
- 批准号:
8912574 - 财政年份:2014
- 资助金额:
$ 41.53万 - 项目类别:
Novel Approaches for Linking Air Quality Mixtures, Climate, and Human Health
将空气质量混合物、气候和人类健康联系起来的新方法
- 批准号:
9123594 - 财政年份:2014
- 资助金额:
$ 41.53万 - 项目类别:
Novel Approaches for Linking Air Quality Mixtures, Climate, and Human Health
将空气质量混合物、气候和人类健康联系起来的新方法
- 批准号:
8923273 - 财政年份:2014
- 资助金额:
$ 41.53万 - 项目类别:
Novel Approaches for Linking Air Quality Mixtures, Climate, and Human Health
将空气质量混合物、气候和人类健康联系起来的新方法
- 批准号:
8618568 - 财政年份:2013
- 资助金额:
$ 41.53万 - 项目类别:
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