Enhancing the IMHRD cohort to support study of the exposome in autoimmune disease

加强 IMHRD 队列以支持自身免疫性疾病暴露组研究

• 批准号: 10871488
• 负责人: John Lanier Pearce
• 金额: $ 41.53万
• 依托单位: MEDICAL UNIVERSITY OF SOUTH CAROLINA
• 依托单位国家: 美国
• 财政年份: 2023
• 资助国家: 美国
• 起止时间: 2023-09-18 至 2025-08-31
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10871488
• 关键词: Address; Advisory Committees; African American; African American population; African ancestry; Autoimmune; Autoimmune Diseases; Award; Biological; Biological Monitoring; Chemical Exposure; Chemicals; Clinical Research; Collaborations; Communities; Complex; Data; Data Science; Diagnosis; Disease Outcome; Electronic Health Record; Environment; Environmental Exposure; Environmental Risk Factor; Epidemiology; Epigenetic Process; Exposure to; Family; Female; Fishes; Funding; Genes; Genetic; Goals; Health; Immune System Diseases; Island; Life Cycle Stages; Link; Lupus; Mahi-Mahi; Maps; Measures; Medical; Methodology; Molecular; National Institute of Arthritis, and Musculoskeletal, and Skin Diseases; National Institute of Environmental Health Sciences; National Institute on Minority Health and Health Disparities; Neighborhoods; Ontology; Outcome; Participant; Patients; Pattern; Phenotype; Poly-fluoroalkyl substances; Population; Population Database; Positioning Attribute; Prevalence; Research; Resolution; Resources; Rheumatism; Science; Scleroderma; Sea; Selection Criteria; Severities; Site; South Carolina; Statistical Data Interpretation; Systemic Lupus Erythematosus; Systemic Scleroderma; United States National Institutes of Health; Universities; clinical center; cohort; demographics; design; epigenomics; genetic analysis; health disparity; high dimensionality; human population genetics; improve minority health; improved; innovation; interest; method development; novel; population health; recruit; response; sample collection; social; study population; tool

ABSTRACT Systemic sclerosis (SSc) and Systemic lupus erythematosus (SLE, or lupus) are autoimmune diseases with disproportionate prevalence and severity burdens among females of African ancestry (AA). Several environmental risk factors are suspected to play a role; however, relationships are complex and difficult to assess, thus much remains unknown. It is clear there is a critical need to improve studies of environmental exposure and autoimmune disease. In response, NIH has released a Notice of Special Interest entitled: “EXposome in Autoimmune Disease Collaborating Teams PLANning Awards (EXACT-PLAN)” intended to advance the study of the exposome in autoimmune diseases. This project is designed to contribute to this effort by establishing collaborations, study populations, and analytic approaches required to better characterize and assess holistic environmental exposures in health studies on autoimmune disease. We are well positioned to achieve this goal, as we leverage resources within the NIAMS-funded Improving Minority Health in Rheumatic Diseases (IMHRD) Core Center for Clinical Research at the Medical University of South Carolina (MUSC), which focuses on two autoimmune diseases, systemic sclerosis (SSc) and systemic lupus erythematosus (SLE), will be leveraged. In addition, we present a strong research team with expertise in exposure science, epidemiology, human population genetics, social epigenomics, and clinical research necessary to improve exposome research on autoimmune disease. The overarching objective of this project is to improve understanding of how environmental exposures influence autoimmune disease. Goals are to develop resources needed to address the exposome within our study populations, develop innovative methodologies that will improve exposome studies, and to establish our research group as a major contributor to national research efforts centered on the exposome. The motivating hypothesis is that variability in environmental exposure (across the life course) is associated with worse autoimmune disease outcomes. The first specific aim focuses on establishing a cohort within the IMHRD study population that will support comprehensive characterization of the exposome. This also includes recruitment of 100 additional participants to enhance our existing study population specifically for exposome research. The second aim will develop novel data science tools to enhance integration and analysis of genetic, environmental, epigenetic, and social measures across the life course. Accomplishing these aims will establish a unique, health disparity cohort with autoimmune disease tailored specifically for exposome research, contribute findings that will improve understanding of complex links between the environment and autoimmune disease, and provide novel data science tools that will improve methodologies for analysis of the exposome.

抽象的 系统性硬化症（SSc）和系统性红斑狼疮（SLE，或狼疮）是自身免疫性疾病 非洲血统女性 (AA) 的患病率和严重程度负担不成比例。一些 怀疑环境风险因素发挥了作用；但关系复杂且难以处理 评估，因此还有很多未知。显然，迫切需要改进环境研究 暴露和自身免疫性疾病。作为回应，NIH 发布了一份特别关注通知，标题为： “自身免疫性疾病 EXposome 合作团队 PLANning 奖 (EXACT-PLAN)”旨在 推进自身免疫性疾病暴露组的研究。该项目旨在为这一努力做出贡献 通过建立合作、研究人群和更好地描述和分析所需的分析方法 评估自身免疫性疾病健康研究中的整体环境暴露。我们有能力 实现这一目标，因为我们利用 NIAMS 资助的改善少数民族风湿病健康项目中的资源 南卡罗来纳医科大学 (MUSC) 疾病 (IMHRD) 临床研究核心中心， 重点关注两种自身免疫性疾病，系统性硬化症（SSc）和系统性红斑狼疮（SLE）， 被杠杆化。此外，我们还拥有一支强大的研究团队，在暴露科学、流行病学、 改进暴露组研究所需的人口遗传学、社会表观基因组学和临床研究 关于自身免疫性疾病。该项目的总体目标是提高对如何 环境暴露会影响自身免疫性疾病。目标是开发解决以下问题所需的资源 我们的研究人群中的暴露组，开发创新方法来改善暴露组研究， 并建立我们的研究小组，作为以暴露组为中心的国家研究工作的主要贡献者。 激励性假设是，环境暴露的变化（在整个生命过程中）与 更糟糕的自身免疫性疾病结果。第一个具体目标是在 IMHRD 内建立一个队列 研究人群将支持暴露组的全面表征。这还包括 招募 100 名额外参与者以增强我们现有的暴露组研究人群 研究。第二个目标是开发新颖的数据科学工具，以加强遗传、 整个生命过程中的环境、表观遗传和社会措施。实现这些目标将建立 专门为暴露组研究量身定制的独特的自身免疫性疾病健康差异队列，有助于 这些发现将增进对环境与自身免疫性疾病之间复杂联系的理解， 并提供新颖的数据科学工具，以改进暴露组分析的方法。