Enhancing the IMHRD cohort to support study of the exposome in autoimmune disease

加强 IMHRD 队列以支持自身免疫性疾病暴露组研究

• 批准号: 10871488
• 负责人: John Lanier Pearce
• 金额: $ 41.53万
• 依托单位: MEDICAL UNIVERSITY OF SOUTH CAROLINA
• 依托单位国家: 美国
• 财政年份: 2023
• 资助国家: 美国
• 起止时间: 2023-09-18 至 2025-08-31
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10871488
• 关键词: Address; Advisory Committees; African American; African American population; African ancestry; Autoimmune; Autoimmune Diseases; Award; Biological; Biological Monitoring; Chemical Exposure; Chemicals; Clinical Research; Collaborations; Communities; Complex; Data; Data Science; Diagnosis; Disease Outcome; Electronic Health Record; Environment; Environmental Exposure; Environmental Risk Factor; Epidemiology; Epigenetic Process; Exposure to; Family; Female; Fishes; Funding; Genes; Genetic; Goals; Health; Immune System Diseases; Island; Life Cycle Stages; Link; Lupus; Mahi-Mahi; Maps; Measures; Medical; Methodology; Molecular; National Institute of Arthritis, and Musculoskeletal, and Skin Diseases; National Institute of Environmental Health Sciences; National Institute on Minority Health and Health Disparities; Neighborhoods; Ontology; Outcome; Participant; Patients; Pattern; Phenotype; Poly-fluoroalkyl substances; Population; Population Database; Positioning Attribute; Prevalence; Research; Resolution; Resources; Rheumatism; Science; Scleroderma; Sea; Selection Criteria; Severities; Site; South Carolina; Statistical Data Interpretation; Systemic Lupus Erythematosus; Systemic Scleroderma; United States National Institutes of Health; Universities; clinical center; cohort; demographics; design; epigenomics; genetic analysis; health disparity; high dimensionality; human population genetics; improve minority health; improved; innovation; interest; method development; novel; population health; recruit; response; sample collection; social; study population; tool

ABSTRACT Systemic sclerosis (SSc) and Systemic lupus erythematosus (SLE, or lupus) are autoimmune diseases with disproportionate prevalence and severity burdens among females of African ancestry (AA). Several environmental risk factors are suspected to play a role; however, relationships are complex and difficult to assess, thus much remains unknown. It is clear there is a critical need to improve studies of environmental exposure and autoimmune disease. In response, NIH has released a Notice of Special Interest entitled: “EXposome in Autoimmune Disease Collaborating Teams PLANning Awards (EXACT-PLAN)” intended to advance the study of the exposome in autoimmune diseases. This project is designed to contribute to this effort by establishing collaborations, study populations, and analytic approaches required to better characterize and assess holistic environmental exposures in health studies on autoimmune disease. We are well positioned to achieve this goal, as we leverage resources within the NIAMS-funded Improving Minority Health in Rheumatic Diseases (IMHRD) Core Center for Clinical Research at the Medical University of South Carolina (MUSC), which focuses on two autoimmune diseases, systemic sclerosis (SSc) and systemic lupus erythematosus (SLE), will be leveraged. In addition, we present a strong research team with expertise in exposure science, epidemiology, human population genetics, social epigenomics, and clinical research necessary to improve exposome research on autoimmune disease. The overarching objective of this project is to improve understanding of how environmental exposures influence autoimmune disease. Goals are to develop resources needed to address the exposome within our study populations, develop innovative methodologies that will improve exposome studies, and to establish our research group as a major contributor to national research efforts centered on the exposome. The motivating hypothesis is that variability in environmental exposure (across the life course) is associated with worse autoimmune disease outcomes. The first specific aim focuses on establishing a cohort within the IMHRD study population that will support comprehensive characterization of the exposome. This also includes recruitment of 100 additional participants to enhance our existing study population specifically for exposome research. The second aim will develop novel data science tools to enhance integration and analysis of genetic, environmental, epigenetic, and social measures across the life course. Accomplishing these aims will establish a unique, health disparity cohort with autoimmune disease tailored specifically for exposome research, contribute findings that will improve understanding of complex links between the environment and autoimmune disease, and provide novel data science tools that will improve methodologies for analysis of the exposome.

摘要 系统性硬化症（SSc）和系统性红斑狼疮（SLE或狼疮）是自身免疫性疾病， 非洲血统女性的患病率和严重程度负担不成比例（AA）。几 环境风险因素被怀疑发挥作用;然而，关系是复杂的，很难 所以，有很多事情是未知的。很明显，迫切需要改善环境研究， 暴露和自身免疫性疾病。作为回应，NIH发布了一份特别关注的通知，标题为： “自身免疫性疾病合作团队计划奖（EXACT-PRANNING Awards）”旨在 推进自身免疫性疾病中的蛋白质组学研究。本项目旨在促进这一努力 通过建立更好地表征和分析所需的合作、研究人群和分析方法 在自身免疫性疾病的健康研究中评估整体环境暴露。我们已准备好 实现这一目标，因为我们利用NIAMS资助的改善少数民族风湿性关节炎患者健康计划内的资源， 南卡罗来纳州医科大学临床研究核心中心（IMHRD）， 重点是两种自身免疫性疾病，系统性硬化症（SSc）和系统性红斑狼疮（SLE），将 被利用。此外，我们还拥有一支强大的研究团队，在暴露科学，流行病学， 人类群体遗传学，社会表观基因组学和临床研究，以改善麻烦的研究 自身免疫性疾病该项目的总体目标是提高对如何 环境暴露影响自身免疫性疾病。目标是开发解决问题所需的资源 在我们的研究人群中遇到麻烦，开发创新的方法，将改善麻烦的研究， 并建立我们的研究小组作为一个主要贡献者的国家研究工作为中心的麻烦。 动机假设是，环境暴露的可变性（在整个生命过程中）与以下因素有关： 自身免疫性疾病的预后更差。第一个具体目标侧重于在IMHRD内建立一个队列 研究人群，将支持全面表征的麻烦。这也包括 招募100名额外的参与者，以增加我们现有的研究人群，特别是针对疑难杂症 research.第二个目标是开发新的数据科学工具，以加强遗传、 环境、表观遗传和社会措施贯穿整个生命过程。实现这些目标将建立 一个独特的，健康差异队列与自身免疫性疾病专门为麻烦的研究， 这些发现将提高对环境和自身免疫性疾病之间复杂联系的理解， 并提供新的数据科学工具，以改进分析问题的方法。