Enhancing the IMHRD cohort to support study of the exposome in autoimmune disease

加强 IMHRD 队列以支持自身免疫性疾病暴露组研究

• 批准号: 10871488
• 负责人: John Lanier Pearce
• 金额: $ 41.53万
• 依托单位: MEDICAL UNIVERSITY OF SOUTH CAROLINA
• 依托单位国家: 美国
• 财政年份: 2023
• 资助国家: 美国
• 起止时间: 2023-09-18 至 2025-08-31
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10871488
• 关键词: Address; Advisory Committees; African American; African American population; African ancestry; Autoimmune; Autoimmune Diseases; Award; Biological; Biological Monitoring; Chemical Exposure; Chemicals; Clinical Research; Collaborations; Communities; Complex; Data; Data Science; Diagnosis; Disease Outcome; Electronic Health Record; Environment; Environmental Exposure; Environmental Risk Factor; Epidemiology; Epigenetic Process; Exposure to; Family; Female; Fishes; Funding; Genes; Genetic; Goals; Health; Immune System Diseases; Island; Life Cycle Stages; Link; Lupus; Mahi-Mahi; Maps; Measures; Medical; Methodology; Molecular; National Institute of Arthritis, and Musculoskeletal, and Skin Diseases; National Institute of Environmental Health Sciences; National Institute on Minority Health and Health Disparities; Neighborhoods; Ontology; Outcome; Participant; Patients; Pattern; Phenotype; Poly-fluoroalkyl substances; Population; Population Database; Positioning Attribute; Prevalence; Research; Resolution; Resources; Rheumatism; Science; Scleroderma; Sea; Selection Criteria; Severities; Site; South Carolina; Statistical Data Interpretation; Systemic Lupus Erythematosus; Systemic Scleroderma; United States National Institutes of Health; Universities; clinical center; cohort; demographics; design; epigenomics; genetic analysis; health disparity; high dimensionality; human population genetics; improve minority health; improved; innovation; interest; method development; novel; population health; recruit; response; sample collection; social; study population; tool

ABSTRACT Systemic sclerosis (SSc) and Systemic lupus erythematosus (SLE, or lupus) are autoimmune diseases with disproportionate prevalence and severity burdens among females of African ancestry (AA). Several environmental risk factors are suspected to play a role; however, relationships are complex and difficult to assess, thus much remains unknown. It is clear there is a critical need to improve studies of environmental exposure and autoimmune disease. In response, NIH has released a Notice of Special Interest entitled: “EXposome in Autoimmune Disease Collaborating Teams PLANning Awards (EXACT-PLAN)” intended to advance the study of the exposome in autoimmune diseases. This project is designed to contribute to this effort by establishing collaborations, study populations, and analytic approaches required to better characterize and assess holistic environmental exposures in health studies on autoimmune disease. We are well positioned to achieve this goal, as we leverage resources within the NIAMS-funded Improving Minority Health in Rheumatic Diseases (IMHRD) Core Center for Clinical Research at the Medical University of South Carolina (MUSC), which focuses on two autoimmune diseases, systemic sclerosis (SSc) and systemic lupus erythematosus (SLE), will be leveraged. In addition, we present a strong research team with expertise in exposure science, epidemiology, human population genetics, social epigenomics, and clinical research necessary to improve exposome research on autoimmune disease. The overarching objective of this project is to improve understanding of how environmental exposures influence autoimmune disease. Goals are to develop resources needed to address the exposome within our study populations, develop innovative methodologies that will improve exposome studies, and to establish our research group as a major contributor to national research efforts centered on the exposome. The motivating hypothesis is that variability in environmental exposure (across the life course) is associated with worse autoimmune disease outcomes. The first specific aim focuses on establishing a cohort within the IMHRD study population that will support comprehensive characterization of the exposome. This also includes recruitment of 100 additional participants to enhance our existing study population specifically for exposome research. The second aim will develop novel data science tools to enhance integration and analysis of genetic, environmental, epigenetic, and social measures across the life course. Accomplishing these aims will establish a unique, health disparity cohort with autoimmune disease tailored specifically for exposome research, contribute findings that will improve understanding of complex links between the environment and autoimmune disease, and provide novel data science tools that will improve methodologies for analysis of the exposome.

摘要 系统性硬化症(SSC)和系统性红斑狼疮(SLE，或狼疮)是自身免疫性疾病 非洲血统女性(AA)的患病率和严重负担不成比例。几个 环境风险因素被怀疑起了作用；然而，关系复杂，很难 因此，仍有许多事情是未知的。显然，迫切需要改进对环境的研究 暴露和自身免疫性疾病。作为回应，NIH发布了一份特别关注通知，题为： “Exposome在自身免疫性疾病合作团队计划大奖(Exposome in Auto免疫性疾病)(Exposome in Auto免疫性疾病Collaboration Teams)(Exposome in Auto免疫性疾病Collaborating Teams)(Exposome in Auto免疫性疾病Collaborating Teams Producting Awards(Exposome in Auto免疫病Collaborating Teams Producting Awards)(Exposome in Auto免疫性疾病Collaborating Teams Producting Awards(Exposome In Autoally Disease Collaborating Teams)(Exposome in Atact-PLAN))》意在 推进自身免疫性疾病暴露组的研究。该项目旨在为这一努力做出贡献。 通过建立协作、研究群体和分析方法来更好地描述和 在自身免疫性疾病的健康研究中评估整体环境暴露。我们处于有利地位，可以 实现这一目标，因为我们利用NIAMS资助的改善风湿病少数民族健康的资源 南卡罗来纳医科大学(MUSC)疾病(IMHRD)临床研究核心中心， 专注于两种自身免疫性疾病，系统性硬化症(SSC)和系统性红斑狼疮(SLE)，Will 发挥杠杆作用。此外，我们还拥有一支强大的研究团队，在接触科学、流行病学、 人类群体遗传学、社会表观基因组学和改善暴露组研究所需的临床研究 关于自身免疫性疾病。该项目的总体目标是提高对如何 环境暴露会影响自身免疫性疾病。目标是开发所需的资源来解决 在我们的研究人群中进行曝光，开发创新的方法来改进曝光研究， 并将我们的研究小组建立为以曝光组为中心的国家研究工作的主要贡献者。 激励假设是，环境暴露的可变性(在整个生命过程中)与 更糟糕的自身免疫性疾病结果。第一个具体目标是在人力资源综合管理系统内建立一个队列 研究人群将支持对曝光组的全面描述。这还包括 招募100名额外参与者，以扩大我们现有的专门针对曝光的研究对象 研究。第二个目标是开发新的数据科学工具，以加强遗传、 整个生命过程中的环境、表观遗传和社会指标。实现这些目标将建立 一个独特的健康差异队列与自身免疫性疾病特别为暴露研究量身定做，贡献 这些发现将提高对环境和自身免疫性疾病之间复杂联系的理解， 并提供新的数据科学工具，这些工具将改进分析暴露组的方法。