Development of a mechanically biomcompatible hip replacement implant with Ti-6Al-4V open-cell microlattice architecture

全髋关节置换术(THA)是一种普通的手术，它包括移除和替换受损的髋关节 人工股骨头和髋臼假体。虽然运行总体上是成功的，但现有的 植入物通常被限制在15年内，之后需要再次手术。据估计，到2030年，对石油的需求 初级THA将增长174%。其中，需要修改的预计将增加137%。 翻修手术比首次全髋关节置换术有更多的并发症。使程序变得复杂的因素包括 去除故障部件，现有骨的质量，骨组织的重建，并固定 新植入的骨头。其中，旧种植体周围骨质量的好坏对修复成功至关重要。 翻修手术。如果剩余的骨不能为新的种植体提供机械基础，假体 不能正确地固定在骨头上。从长远来看，预防骨吸收的能力是 现有的全髋关节植入物。这项研究计划建议开发一种创新的全髋关节植入物，使 在长期内重建周围的骨组织。 植入物将以多种方式影响加拿大的健康和加拿大。第一，治疗需要初级治疗的患者 翻修手术将得到加强。这将极大地提高他们的长期自主性、健康性和 生活。其次，该植入物将降低翻修手术的需求，医疗保健成本大幅下降。第三，当 需要翻修，种植体长期保存宿主骨的能力将使翻修手术取得成功 作为主要的THA。

Total hip arthroplasty (THA) is an ordinary surgery that involves the removal and replacement of the damaged hip joint with an artificial femoral head and acetabular cup. Although the operation is generally successful, the service life of existing implants is generally limited to 15 years, after which another surgery is required. It is estimated that by 2030 the demand for primary THA will grow by 174%. Among them, those requiring revision are projected to increase by 137%. Revision surgery presents more complications than a first-time THA. Factors that make the procedure complex include the removal of the failed components, the quality of the existing bone, the reconstruction of bone tissue, and the fixing of the new implant to the bone. Among these, the quality of the bone surrounding the old implant is crucial to the success of a revision surgery. If the remaining bone is unable to provide a mechanical foundation for the new implant, the prosthesis cannot be properly fixed to the bone. The ability to prevent bone resorption in the long term is one major bottle neck of existing THA implants. This research program proposes the development of an innovative THA implant that allows the surrounding bone tissue to remodel in the long term. The implant will impact Canadian health and Canada in a multitude of ways. First, the treatment of patients requiring primary and revision THA surgery will be enhanced. This will dramatically improve their long-term autonomy, health and standard of life. Second, the implant will lower the need of revision surgery, with a drastic drop in health care costs. Third, when THA revision is needed, the implant capacity of preserving the host bone in the long term will make revision surgery as successful as primary THA.