Development of a toxicity index for metabolites associated to chemical and/or biological degradation from petroleum products

在加拿大和魁北克，石油碳氢化合物对土地的污染代表着一股潮流和 严重的环境问题。尽管石油的降解技术(化学和/或生物) 产品在行业中被广泛使用，以往的研究只评估了全球实现的百分比 退化。最终，碳氢化合物的分解将导致脂肪酸、醇的形成。 和二氧化碳，但在这个过程中可能会出现比原始产品更多的有毒代谢物。因此，它是 非常重要的是制定毒性指数来表征与以下物质有关的有毒代谢物 石油产品的降解。Enutech Inc.是一家位于魁北克省庞特克莱尔的公司，专门从事 受污染土地和地下水的特征以及土壤修复方法。Enutech Inc. 使用一种越来越受赞誉的技术作为就地治疗来修复受污染的地点。不过，这个 石油产品的降解方法不是最优的，降解产生的代谢产物的毒性影响 原生碳氢化合物的来源没有得到澄清。在这种情况下，Enutech Inc.有兴趣评估 原位处理过程中不同降解途径代谢物的毒性影响 以确定哪种降解途径产生的毒性影响最小。要解决这个问题， Enutech Inc.，该项目旨在评估从化学和/或 生物降解技术，进而开发出可靠的毒性指数，可用于现场 被污染的土地。因此，与我在UQ？M的研究实验室的这种合作关系对Enutech来说是必不可少的 因为我们在生物测试毒性测试领域拥有强大的专业知识。多年来，我们有 一直致力于研究几种污染物的毒性机制，以开发风险评估生物测定方法 使用藻类和水生植物。这一可靠方法的开发将使快速检测 石油代谢物引起的毒性。因此，该项目将使公司能够验证其安全性 其净化技术和获得新水平的专业知识。

In Canada and in Quebec, the contamination of land by petroleum hydrocarbons represents a current and serious environmental problem. Although degradation techniques (chemical and/or biological) of petroleum products are widely used in the industry, previous studies had only evaluated the global achieved percentage of degradation. Ultimately, the decomposition of hydrocarbons will lead to the formation of fatty acids, alcohols and CO2, but more toxic metabolites than the original product can appear during the process. Therefore, it is of great importance to develop a toxicity index for the characterization of toxic metabolites associated to petroleum products degradation. Enutech inc. is a firm located in Pointe-Claire (Québec) and specialized in the characterization of contaminated land and groundwater as well as in soil remediation approaches. Enutech inc. uses a more and more acclaimed technique as in situ treatment to rehabilitate contaminated sites. However, this method for oil products degradation is not optimal and the toxicity impact of degradation generated metabolites from original hydrocarbons is not elucidated. In this context, Enutech inc. is interested in to evaluate the toxicity impact of metabolites related to different route of degradation during in situ treatment processing and to determine which degradation pathway generates the lowest toxicity impact. To solve this problematic of Enutech inc., this project consist to assess the toxicity of petroleum metabolites obtained from chemical and/or biological degradation techniques and then to develop a reliable toxicity index which can be used for in-situ contaminated land. Therefore, this partnership with my research laboratory at UQÀM is essential for Enutech inc., since we possess a strong expertise in the field of bioassay toxicity testing. During many years, we have been working in toxicity mechanisms of several pollutants for the development of risk assessment bioassays using algae and aquatic plants. The development of this reliable method will permit a rapid detection of toxicity induced by petroleum metabolites. Therefore, this project will allow the company to validate the safety of its decontamination techniques and accessing a new level of expertise.