A computational modelling framework for identifying smart vaccination strategies

临床阶段的生物制药公司Medicago开发了一种非常创新的生产方法，这种方法有可能在确定流感病毒株的基因序列后3周内开发出用于测试的疫苗，从而能够在疫情爆发期间很早就对人群进行大规模疫苗接种。该公司想知道在流感大流行的情况下，需要接种多少剂疫苗，以及应该使用什么分发策略来最大限度地提高疫苗接种的全民效益。我们将采用以代理人为基础的建模方法，将人口概况、健康指标、疾病特征和新的疫苗技术生产和效果参数的信息纳入其中，以确定所需的疫苗剂量和分发率。 在疫苗制造能力和交付的限制下。我们将与Medicago沟通这一项目的成果，这将使他们能够预测和提高Medicago的疫苗生产能力，以便Medicago与其全球客户之间能够进行有效的沟通。除了减轻疫情对加拿大经济的负面影响外，Medicago还将使用这项技术来提高其市场份额，并在国内和国际上变得更具竞争力。因此，它将为加拿大经济做出贡献，随着这项技术的改进，它将为加拿大国内创造就业机会和增长提供机会。该项目为HQP学员提供了一个极好的机会，不仅可以利用尖端技术和方法进行世界级的研究，还可以获得涉及应用驱动问题的校外工业经验。

Medicago, a clinical-stage biopharmaceutical company, has developed a very innovative production method, which has the potential to enable the development of a vaccine for testing within 3 weeks of the identification of genetic sequences from an influenza strain, allowing for large-scale vaccination of the population very early during an outbreak. The company would like to know how many doses of vaccine is required and what distribution strategies should be used to maximize population-wide benefits of vaccination in the event of an influenza pandemic. We will apply an agent-based modelling approach to incorporate information on population profiles; health indicators; disease characteristics; and novel vaccine technology production and effectiveness parameters in order to determine the required number of vaccine doses and distribution rates under constraints of vaccine manufacturing capacity and delivery. We will communicate the outcomes of this project with Medicago, which will enable them to project and improve Medicago's vaccine production capacity, so that effective communications can take place between Medicago and its customers worldwide. In addition to mitigating the negative effects of a pandemic on the Canadian economy, Medicago will use this technology to improve its market share and to become more competitive nationally and internationally. It will thereby contribute to the Canadian economy, and as this technology improves, it will provide opportunities for job creation and growth within Canada. This project provides an excellent opportunity for HQP trainees to leverage cutting edge techniques and methodologies for performing world-class research, but also to gain off-campus industrial experience involving applied-driven problems.