Evolution of Potassium Channels and Nerve Networks in Cnidaria

所有动物都有神经系统--由可兴奋细胞组成的组织，它们在身体的不同部位之间传递和整合信息。 神经系统的结构和活动在生物体之间有很大的差异，从相对分散的刺胞动物的神经网络到解剖学上不同的双侧动物的集中神经系统。 然而，所有动物的神经系统的所有细胞都是电反应的。离子通道蛋白质，配体门控的，其响应于突触处的神经递质和突触外调节信号，以及电压门控的，其响应于膜电位的变化，调节膜电位。 该提案描述了一个旨在识别和表征刺胞动物中电压门控钾通道的计划，

All animals have nervous systems – tissues formed of excitable cells that transmit and integrate information between different parts of the body. The structure and activity of nervous systems varies widely between organisms, from the relatively dispersed neural networks of the Cnidaria to the many anatomically different centralized nervous systems of the Bilateria. However, all cells of the nervous systems of all animals are electrically responsive. Ion channel proteins, both ligand-gated, which respond to neurotransmitters at the synapse and extra-synaptic modulatory signals, and voltage-gated, which respond to changes in membrane potential, modulate the membrane potential. This proposal describes a program aimed at identifying and characterizing the voltage-gated potassium channels in the cnidarian,