New Synthetic Strategies & Methods for Bioactive Aromatics and Heteroaromatics

今天，推动生物和材料科学进步的是制造分子的科学和艺术——化学合成。它允许实际供应难以或不可能以其他方式获得的药品和材料；它对人类健康（大多数治疗剂都是合成衍生的）和我们的生活水平（纳米管、导电聚合物、智能手机、传感器）产生了深远的影响。合成领域的基本发现是几十年后产生实际影响的核心，例如2010年诺贝尔奖和2014年诺贝尔奖（授予光学显微镜“让我们窥视纳米世界”和追踪阿尔茨海默病等），都是基于有机合成。对RNA和DNA关系的理解取决于有机化学家提出的“为什么核酸是戊糖而不是己糖？”这样的问题，这将使我们了解生命是如何开始的（我们的益生元起源）。在应用于社会之前，这些基本问题必须得到回答，通常是20年后。

Today, driving most advances in biology and material science is the science and art of making molecules – chemical synthesis. It allows for the practical supply of medicinals and materials that are difficult or impossible to acquire otherwise; it has profound consequences on human health (most therapeutic agents are synthesis-derived) and our standards of living (nanotubes, conducting polymers, smart phones, sensors). Fundamental discoveries in synthesis are at the heart of practical impact decades later, e.g. the 2010 Nobel and the 2014 Nobel (awarded for optical microscopy “allowing us to peer into the nanoworld” and track e.g. Alzheimer disease), is based on organic synthesis. The understanding of relationship of RNA and DNA is dependent on questions such as “why pentose and not hexose nucleic acids?” asked by organic chemists which will allow understanding of how life began (our prebiotic origins). Such basic questions must be answered before application in society, usually 20 years hence, can result.