Bioinorganic chemistry of metalloproteins and synthetic analogues

该研究涉及金属及其宿主分子的生物功能，以及合成类似物技术应用的性质预测。金属在生物系统中控制着所有的生命，在许多情况下是通过与蛋白质肽链中氨基酸的供体原子结合而实现的。金属离子也与特定的螯合剂结合，然后激活蛋白质的功能。金属是催化、维持细胞离子强度、形成结构材料和通过与氨基酸配位控制蛋白质折叠的活性位点。虽然所有生物体都需要各种金属，但这些金属离子的供应和可用性必须在细胞中进行调节，以避免缺乏导致功能压力，而过量则导致毒性。

The research to be carried out concerns the biological functionality of metals and their host molecules, and the prediction of properties for technological applications of synthetic analogues. Metals in biological systems control all life, in many cases by binding to the donor atoms of amino acids in the peptide chains of proteins. Metal ions also bind to specific chelators that then activate proteins for function. Metals are the active site for catalysis, maintain cellular ionic strength, form structural materials and control protein folding through their coordination to amino acids. While all organisms require a variety of metals, the supply and availability of these metal ions must be regulated in the cell to avoid deficiency, leading to functional stress, while an excess leads to toxicity.