Stress field within biological tissues from multiparametric Magnetic Resonance Imaging

生物组织的重塑在很大程度上是由于细胞所承受的机械应力。在许多疾病中，组织机械损伤与引起生物变化的机械应力分布紊乱有关。这些生物变化产生结构变化，进而改变机械性能和应力分布，导致“恶性循环”。我相信，对生物组织内机械应力的评估是理解人类基本过程的基石，并将使我们能够制定新的策略来打破这种“恶性循环”。我的研究项目的长期目标是提供新的诊断成像和建模技术，用于在肌肉骨骼或心脏组织中进行强大的体内机械应力评估，以进一步预测人体组织的降解和再生。

Biological tissues remodeling is largely due to the mechanical stresses withstood by the cells. In many diseases, tissue mechanical damage is associated to a perturbed mechanical stress distribution that triggers biological changes. These biological changes produce structural changes that in turn modify the mechanical properties and stress distribution, resulting in a “vicious cycle”. I believe that the evaluation of the mechanical stresses within biological tissues is a cornerstone in understanding of fundamental processes in humans and would enable defining new strategies to break this “vicious cycle”. The long-term objective of my research program is to provide new diagnostic imaging and modeling technologies for the robust in vivo mechanical stresses evaluation within musculoskeletal or cardiac tissues for further prediction of human tissues degradation and regeneration.