Development of innovative optical technologies for quantitative blood perfusion imaging

我们需要一种光谱域光学相干断层成像(SD-OCT)系统，用于无创高速血液灌流测量和高分辨率组织结构成像。所需的工具和仪器将与现有设备整合，并整合到我们在蒙特雷亚尔圣胡斯丁大学的共同生物医学成像设施中。在过去的二十年里，随着非侵入性光学仪器的发展，生物医学成像技术取得了巨大的进步，可以测量特定的参数，如血氧饱和度、血流指数和血容量。然而，微血管血流灌注的非侵入性测量仍然具有挑战性，而且往往受到实际和技术问题的限制。SD-OCT是一种相对较新且非常有前景的测量血液灌注量和组织结构的技术。SD-OCT仪器的最新进展为关键成像应用的高速、高分辨率和史无前例的渗透提供了所需的灵活性。然而，圣贾斯丁大学、Maisonneuve-Rosemont医院、巴黎理工学院和蒙特雷亚尔大学现有的OCT系统都是临床设备，不支持血液灌流成像所需的高速数据采集方案。如果没有研究所需的具体灵活性，就不可能调整或升级这些严格实施到有限数据采集成像率的系统。因此，由于这种情况，圣贾斯丁州立大学和蒙特雷亚尔大学在生物医学成像方面的进一步进展和进展受到限制。来自Maisonneuve-Rosemont大学和巴黎高等理工学院的顶尖光学物理学家作为当前申请的共同申请者和合作者所做的承诺，表明了获得和开发拟议的SD-OCT平台的必要性和紧迫性。CHU Sainte-Justine研究中心提供的资金匹配支持进一步支持了购买拟议设备的紧迫性。随着生物医学成像在圣贾斯丁州立大学和蒙特雷亚尔大学全面兴起，这个新平台将使现有的和新的合作产生的研究项目受益，因此社区将继续增长。这些研究活动可能会在生物医学成像科学领域产生大量的HQP，这将提高研究质量和所有团队成员实验室的声誉。

We are requesting a spectral-domain optical coherence tomography (SD-OCT) system for non-invasive high-speed blood perfusion measurement and high-resolution tissue architecture imaging. Requested tools and instruments will be integrated with existing equipment and consolidated in our common Facility for Biomedical Imaging at CHU Sainte-Justine in Montréal. The last two decades have seen great progress in biomedical imaging with the development of non-invasive optical instruments to measure specific parameters such as haemoglobin oxygen saturation, blood flow index and blood volume. Nevertheless, non-invasive measurement of microvascular blood perfusion remains challenging and is often limited by practical and technological issues. A relatively recent and extremely promising technique to measure blood perfusion and tissue architecture is SD-OCT. Recent advances in SD-OCT instrumentation provide the flexibility required for high-speed, high-resolution and unprecedented penetration for critical imaging applications. However, the existing OCT systems available at CHU Sainte-Justine, Hôpital Maisonneuve-Rosemont, École Polytechnique and Université de Montréal are clinical devices that do not allow high-speed data acquisition schemes needed for blood perfusion imaging. It is not possible to adapt or upgrade these systems, strictly implemented to limited data acquisition imaging rates, without the specific flexibility needed for research. Further progress and advance in biomedical imaging is thus limited at CHU Sainte-Justine and in Montréal due to this situation. The commitment of leading optical physicists from Hôpital Maisonneuve-Rosemont and École Polytechnique, as co-applicants and collaborators in the current application, is demonstrating the need and urgency of acquiring and developing the proposed SD-OCT platform. Funding matching support from the CHU Sainte-Justine Research center is additionally supporting the urgency in acquiring the proposed equipment. As biomedical imaging is in full emergence at CHU Sainte-Justine and in Montréal, this new platform will benefit research projects emerging from existing and new collaborations, and therefore the community will continue to grow. These research activities will likely generate a large number of HQP in biomedical imaging sciences, which will increase the quality of research and reputation of all team members’ laboratories.