Development of new bedside optical imaging methods for non-invasive assessment of brain injury in neonates

开发新的床边光学成像方法，用于新生儿脑损伤的无创评估

• 批准号: RGPIN-2015-04672
• 负责人: Dehaes, Mathieu
• 金额: $ 1.6万
• 依托单位: Université de Montréal
• 依托单位国家: 加拿大
• 项目类别: Discovery Grants Program - Individual
• 财政年份: 2017
• 资助国家: 加拿大
• 起止时间: 2017-01-01 至 2018-12-31
• 项目状态: 已结题
• 来源: https://www.nserc-crsng.gc.ca/ase-oro/Details-Detailles_eng.asp?id=632953
• 关键词: Development; new; bedside; optical; imaging

The neonatal brain is particularly vulnerable to the biological consequences of prematurity, to birth asphyxia, congenital heart disease and other neonatal metabolic disorders. Brain injury and altered or delayed brain development in the neonatal period are associated with devastating neurodevelopmental consequences such as significant cognitive, motor, language and behavioural disabilities. Although mortality rates have decreased due to advances in clinical care, neurodevelopmental deficits have emerged as the most significant co-morbidity. Currently the lack of bedside quantitative tools to monitor and assess brain health is a critical barrier to improve outcome in at-risk neonates.

新生儿大脑特别容易受到早产、出生窒息、先天性心脏病和其他新生儿代谢紊乱的生物学后果的影响。新生儿期的脑损伤和大脑发育改变或延迟与破坏性的神经发育后果有关，例如严重的认知、运动、语言和行为障碍。尽管由于临床护理的进步，死亡率有所下降，但神经发育缺陷已成为最重要的合并症。目前，缺乏监测和评估大脑健康的床边定量工具是改善高危新生儿预后的关键障碍。