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Therapeutic strategies for improvement of airway epithelial repair by targeting CFTR defect and bacterial infection in cystic fibrosis patients

Therapeutic strategies for improvement of airway epithelial repair by targeting CFTR defect and bacterial infection in cystic fibrosis patients
针对囊性纤维化患者CFTR缺陷和细菌感染改善气道上皮修复的治疗策略
批准号：
342747
负责人：
Brochiero Emmanuelle
金额：
$42.61万
依托单位：
Centre hospitalier de l'Universit de Montral (CHUM)
依托单位国家：
加拿大
项目类别：
Operating Grants
财政年份：
2016
资助国家：
加拿大
项目状态：
已结题
起止时间：
2016-03-01 至 2021-03-01
来源：
https://webapps.cihr-irsc.gc.ca/decisions/p/project_details.html?applId=342747&lang=en
关键词：
Airway Epithelial Cells Airway Epithelial Injury Airway Epithelial Repair Bacterial Infection Cftr Cftr Correctors And Potentiators Cystic Fibrosis Lung Disease Pseudomonas Aeruginosa Quorum Sensing

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中文摘要
翻译
囊性纤维化（CF）是高加索人中最常见的遗传性疾病，是由于编码一种名为CFTR的蛋白质的基因发生突变。虽然CF影响许多器官，但由细菌感染引起的进行性肺损伤仍然是m的首要原因
英文摘要
Cystic fibrosis (CF), the most common genetic disease among Caucasians, is due to mutations in the gene coding for a protein called CFTR. Although CF affects many organs, the progressive lung damage due to bacterial infections remains the first cause of m
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Development of innovative therapeutic strategies in cystic fibrosis for improvement of CFTR-targeted treatments and restoration of airway epithelial integrity in infected lungs from patients harboring various mutations
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