Graphene and MoS2-based cell-on-chip electrochemical sensors for detecting post-operative complications

NERv是一家位于滑铁卢的生物医学设备初创公司，在过去两年中开发了一系列传感器，专门用于检测手术后可能出现的并发症。通过检测pH值的变化或细菌的存在来推断并发症。通过与滑铁卢大学Pope Group的合作，NERv的目标是开发一套新的材料，工艺和设备架构，以实现更好的传感性能。合作的主要目标是提高设备的灵敏度和选择性，同时降低设备成本和占地面积。为了实现这一目标，Pope集团将开发单层石墨烯和二硫化钼涂层，其电子特性对环境刺激表现出极端敏感性。这些膜将用对细菌或pH具有选择性并且能够引起显著响应的化学品进行功能化。Waterloo和NERv团队将在项目结束时组装和演示嵌入NERv芯片技术的原型传感器。结果E.该项目中开发的大肠杆菌和pH传感器将为加拿大医疗保健系统提供具有竞争力的技术，这将有助于显着降低手术的许多风险。这一技术的成功商业化将在全世界范围内带来好处，预计这一结果将为加拿大企业带来可观的收入，对就业增长和改善加拿大经济产生积极影响。

NERv is a biomedical device startup based in Waterloo that has developed a series of sensors over the past two years that are specifically geared towards the detection of complications that can arise after surgery. Complications are inferred by the detection of changes in pH or the presence of bacteria. Through the proposed collaboration with the Pope Group at the University of Waterloo, experts in the synthesis, processing and electrochemistry of 2D materials such as graphene and molybdenum disulfide, NERv aims to develop a new set of materials, processes and device architectures to achieve improved sensing performance. The main goal of the collaborative work will be to improve the device sensitivity and selectivity over their current sensors while reducing the device cost and footprint. To achieve this, the Pope Group will develop coatings of single layer graphene and molybdenum disulfide whose electronic propertis exhibit extreme sensitivity to environmental stimuli. These films will be functionalized with chemicals that are selective to either bacteria or pH and capable of eliciting a significant response. The Waterloo and NERv teams will assemble and demonstrate prototype sensors embedded in NERv's chip-based technology at the end of the project. The resulting E. coli and pH sensors developed in this project will provide a competitive technology to the Canadian healthcare system which will help to significantly mitigate many of the risks of surgery. The successful commercialization of this technology will provide benefits worldwide, a result that is expected to generate significant revenues for Canadian businesses having a positive impact on job growth and improving the Canadian economy.