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What is the cause of chromosome segregation error in the mammalian preimplantation embryo?

What is the cause of chromosome segregation error in the mammalian preimplantation embryo?
哺乳动物植入前胚胎染色体分离错误的原因是什么?
批准号:
357919
负责人:
Fitzharris Greg
金额:
$44.31万
依托单位国家:
加拿大
项目类别:
Operating Grants
财政年份:
2016
资助国家:
加拿大
项目状态:
已结题
起止时间:
2016-10-01 至 2021-10-01

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中文摘要
翻译
新受精胚胎的健康状况是生育能力的重要决定因素。接受生育治疗的女性经常遇到的一个问题是,早期胚胎的细胞染色体数量错误——被称为“非整倍体”细胞
英文摘要
The health of the newly fertilised embryo is an important determinant of fertility. One problem commonly experienced by women undergoing fertility treatments is that the early embryo has cells with the wrong number of chromosomes - termed 'aneuploid' cell
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What is the underlying cause of mosaic aneuploidy in the preimplantation embryo?
The role of the kinetochore in age-related oocyte aneuploidy
Microtubule dynamics and age-related aneuploidy in mammalian oocytes
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