Universal Antibiofilm Coating Solutions for Ureteral Stents

这项研究解决了医院获得性感染的严峻挑战：预防与输尿管支架相关的细菌感染。输尿管支架通常被泌尿外科医生用于治疗肾结石和与癌症、感染等相关的输尿管问题。在难以治疗的医院获得性感染中，尿路装置占80%。除了死亡率增加外，这些并发症还增加了数百万额外的医疗费用。目前，抗生素是我们试图处理这些感染的唯一方法，但由于支架表面生物膜固有的多重耐药性，抗生素效果不佳。该项目基于UBC在开发一种新型通用包衣方法以防止细菌附着和蛋白质结合方面的最新突破，以及发现新型短广谱抗生物膜肽(ABPs)。该项目将发现和发明新的技术，通过在输尿管支架表面开发一种新的涂层来防止感染和其他与支架相关的并发症，这种涂层将防止细菌生长，防止生物分子从尿液中沉积在支架表面，并具有良好的生物相容性。我们预计，开发的技术将帮助300万需要泌尿外科干预的加拿大人。该项目将在自然科学和医学之间建立强有力的合作，并提供独特的HQP培训机会。新型抗感染涂料还将提供一种预防与其他医疗器械相关的感染的通用方法。

This research addresses serious challenge in hospital acquired infections: the prevention of bacterial infections associatedwith ureteral stents. Ureteral stents are commonly used by a urology surgeon in the treatment of kidney stone and ureterproblem associated with cancer, infection etc. Urinary devices account for >80% of hospital acquired infections which aredifficult to treat. In addition to increased mortality, these complications add millions of extra health care costs. Currently,antibiotics are our only method of attempting to deal with these infections, but do not work well due to intrinsic multidrugresistance of biofilms on stent surface. The project is based on the latest breakthroughs at UBC on the development of anovel universal coating method to prevent bacterial attachment and protein binding, and the discovery of novel short broadspectrum anti-bioflim peptides (ABPs). This project will discover and invent novel technologies which can prevent infectionand other stent related complications by developing a novel coating on the ureteral stent surface which will prevent bacterialgrowth, deposition of biological molecules on the stent surface from urine and with excellent biocompatibility. We anticipatethat the technologies developed will help >3 million Canadians who needs urological intervention. The project will establish astrong collaboration among natural science, and medicine, and provide unique HQP training opportunities. The novel antiinfectioncoatings will also provide a general method for preventing infections associated with other medical devices.