Molecular Basis of RING E3 Ligase Pirh2 and HECT E3 Ligase Itch Interaction.

蛋白质是人体中最重要的分子群之一。调节蛋白质的稳定性和周转是细胞中的一项关键任务。大多数蛋白质通过泛素(Ub)-蛋白酶体途径（UPP）降解。UPP影响多种细胞过程和底物，UPP中的缺陷可导致人类疾病的发病机制。UPP在生物学中的核心作用已获得诺贝尔奖

Proteins are one of the most important group of molecules in the human body. Regulation of protein stability and turnover is a key task in the cell. The majority of proteins are degraded by the ubiquitin (Ub)-proteasome pathway (UPP). The UPP affects a wide variety of cellular processes and substrates and defects in the UPP can result in the pathogenesis of human diseases. The central role of the UPP in biology has been recognized with the Nobel Prize