Identification of functional links between redox homeostasis and immunity

氧化还原动态平衡和免疫之间功能联系的鉴定我研究巨噬细胞的生物学，巨噬细胞是有助于免疫防御、组织修复、清除死亡细胞和红细胞生成的细胞。红细胞生成是产生新的红细胞(RBC)以取代衰老的细胞，并确保氧气输送到每个组织和二氧化碳的排除的过程。巨噬细胞对红细胞的生成至关重要，因为巨噬细胞可以哺育未分化的红细胞，并在促红细胞生成素的作用下引导其生长、存活和成熟。在红细胞丢失(出血和其他)的情况下，身体会增加促红细胞生成素的水平来刺激红细胞生成，巨噬细胞的行为也会改变，以增加红细胞的产生。导致巨噬细胞这些变化的因素尚不清楚，重要的是识别它们并了解它们如何影响其生物学，以便制定刺激红细胞再生的策略，并应对以红细胞数量不足为特征的各种情况。为了这项研究的成功，我们将在实验室建立新的诱导红细胞产生的实验模型，并研究巨噬细胞如何确保其在红细胞生成中的护理作用。我们还将研究高水平的促红细胞生成素对巨噬细胞与形成的红细胞的相互作用的影响，巨噬细胞通过分泌生长因子和表达蛋白质来提供紧密的细胞间联系。

Identification of functional links between redox homeostasis and immunityI study the biology of macrophages, which are cells contributing to immune defenses, tissue repair, elimination of dead cells and erythropoiesis. Erythropoiesis is the process by which new red blood cells (RBCs) are generated to replace senescent cells and ensure transport of oxygen to every tissue and elimination of carbon dioxide. Macrophages are essential for erythropoiesis as they nurse non-differentiated RBCs and guide their growth, survival and maturation in response to erythropoietin. In conditions of RBC loss (bleeding and others), the body increases the levels of erythropoietin to stimulate erythropoiesis, and the behavior of macrophages are changed to allow enhanced production of RBCs. The factors leading to these changes in macrophages remain unknown, and it is important to identify them and understand how they affect their biology, in order to develop strategies to stimulate the regeneration of RBCs and to cope with various conditions characterized by insufficient RBC numbers. To succeed in this research we will establish new experimental models to induce the production of RBCs in the laboratory and investigate how macrophages ensure their nursing roles in erythropoiesis. We will also investigate the impact for high levels of erythropoietin on the interactions of macrophages with forming RBCs, which are sustained by their secretion of growth factors and their expression of proteins to provide tight cell to cell contact.