Mitochondrial biogenesis in skeletal muscle

这项研究计划的目的是继续我们正在进行的研究工作，研究定期锻炼对肌肉产生的适应性。我们使用细胞生物学、生物化学和分子方法来理解这一过程。肌肉对运动的一个主要适应是它在称为线粒体的细胞间隔内产生能量（ATP）的能力的提高。线粒体被称为细胞的“发电站”，因为它产生肌肉收缩所需的能量，对维持良好的肌肉代谢健康很重要。定期进行的体育活动（即锻炼）会增加肌肉细胞的线粒体含量，这是一种适应，可以减少疲劳，改善各级体育活动的新陈代谢。众所周知，这种适应发生在包括人类在内的许多动物物种中。这是如何发生的还不完全清楚。这个提议的目的是调查我们的感觉是什么

This research proposal is designed to continue our ongoing work in investigating the adaptations that take place in muscle as a result of regularly performed exercise. We use cell biology, biochemical and molecular approaches to understanding this process. A major adaptation that is well established in muscle in response to exercise is its improved ability to produce energy (ATP) within the cellular compartment called the mitochondrion. The mitochondrion is called the “powerhouse” of the cell, because it generates the energy required for muscle to contract, and it is important for the maintenance of good muscle metabolic health. Regularly performed physical activity (i.e. exercise) produces an increase in the mitochondrial content of muscle cells, an adaptation that results in reduced fatigue and improved metabolism at all levels of physical activity. This adaptation is known to occur across a wide range of animal species, including humans. How this takes place is not fully understood. This purpose of this proposal is to investigate what we feel are