Heterocycles in natural products: Enzymes, pathways, and chemistry

从活着的有机体中分离出来的分子是迄今为止分离出来的一些化学上最复杂、药用上最相关的化合物。这些天然产物分子扮演着抗生素和其他药物的关键角色。我的研究小组对了解自然如何构建天然产品感兴趣，我们的长期目标是利用这一知识开发新的分子，并了解新型酶是如何发挥作用的。在这个项目中，我们将使用吲哚霉素，一种独特的抗生素，具有翻译潜力，作为对抗甲氧西林耐药性的药物。

Molecules isolated from living organisms are some of the most chemically complex and medicinally relevant compounds ever isolated. These natural product molecules play critical roles as antibiotics and other drugs. My research group is interested in understanding how nature constructs natural products, and our long-term goal is to harness this knowledge to develop new molecules and to understand how novel enzymes function. In this program, we will use indolmycin, a unique antibiotic, with translational potential as an agent against methicillin-resistant