Synthesis of complex carbohydrate antigens of pathogenic bacteria

在过去的几十年里，糖生物学的研究不断增加，导致了对碳水化合物的识别，这些碳水化合物在细胞信号和免疫学中发挥着重要的关键作用。荚膜多糖(CPS)和/或脂多糖(LPS)是细菌表面的主要成分。从细菌的CPS或LPS中已经分离出几种较高级的单糖(含有8到11个连续碳原子的单糖)，这些碳水化合物的合成可以获得有价值的潜在抗原分子。医学上相关的2-酮基-磺酸家族具有多种生物学功能，是细菌CPS和/或内毒素的组成部分。尽管多年来进行了广泛的努力，但目前还没有一种通用和实用的方法来合成这些碳水化合物。

During the last few decades, increasing research in glycobiology has led to the identification of carbohydrates that play important key roles in cell signaling and immunology. Capsular polysaccharides (CPS) and/or lipopolysaccharides (LPS) are the major components on the surface of bacteria. Several higher monosaccharides (monosaccharides containing between 8 and 11 consecutive carbon atoms) have been isolated from bacterial CPS or LPS, and the synthesis of these carbohydrates could allow access to valuable potential antigenic molecules. The medically relevant 2-keto-ulosonic acid family have various biological functions and are constituents of bacterial CPS and/or LPS. Despite extensive efforts over the years, there is no general and practical route to the synthesis of these carbohydrates.