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Development of miniaturized multi-organ human skin-vasculature-liver model on chip (SVLOC) for biological investigation of cross-talk of multiple organs

Development of miniaturized multi-organ human skin-vasculature-liver model on chip (SVLOC) for biological investigation of cross-talk of multiple organs
开发小型化多器官人体皮肤-血管-肝脏芯片模型(SVLOC),用于多器官串扰的生物学研究
批准号:
RGPIN-2015-06165
负责人:
SanatiNezhad, Amir
金额:
$1.68万
依托单位:
依托单位国家:
加拿大
项目类别:
Discovery Grants Program - Individual
财政年份:
2017
资助国家:
加拿大
项目状态:
已结题
起止时间:
2017-01-01 至 2018-12-31

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中文摘要
翻译
了解皮肤与其他器官(如呼吸道,胃肠道,特别是肝脏)的串扰至关重要。通过皮肤吸收的化学物质可能在肝脏代谢,而受影响的肝脏也可能影响皮肤。专注于调查这种串扰的研究是有限的,并且由于技术挑战而产生了误导和矛盾的结果。由于皮肤的副作用,有必要建立一种新型的仿生体外多器官模型来研究皮肤与相关器官的串扰。
英文摘要
Understanding the cross-talk of skin with other organs such as the respiratory, gastro-intestinal tract and particularly the liver, is of paramount importance. The chemical absorbed through skin may be metabolized at liver, while the affected liver may also influence the skin. The studies focused on investigating this cross-talk are limited and have produced misleading and contradictory results due to technical challenges. Due to the side effect of dermal There is an essential need to establish a novel biomimetic in vitro multi-organ model to investigate the cross-talk of skin with relevant organs.
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Bio-microelectromechanical Systems (BioMEMS)
  • 批准号:
    CRC-2017-00022
  • 项目类别:
    Canada Research Chairs
  • 资助金额:
    $6.56万
  • 财政年份:
    2022
  • 负责人:
    SanatiNezhad, Amir
  • 依托单位:
Next generation of microfluidic nanosensing platforms for medical diagnostics and environmental monitoring
  • 批准号:
    RGPIN-2020-04580
  • 项目类别:
    Discovery Grants Program - Individual
  • 资助金额:
    $2.84万
  • 财政年份:
    2022
  • 负责人:
    SanatiNezhad, Amir
  • 依托单位:
Bio-microelectromechanical systems
  • 批准号:
    CRC-2021-00474
  • 项目类别:
    Canada Research Chairs
  • 资助金额:
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  • 财政年份:
    2022
  • 负责人:
    SanatiNezhad, Amir
  • 依托单位:
Bio-Microelectromechanical Systems (Biomems)
  • 批准号:
    CRC-2017-00022
  • 项目类别:
    Canada Research Chairs
  • 资助金额:
    $8.74万
  • 财政年份:
    2021
  • 负责人:
    SanatiNezhad, Amir
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国内基金
海外基金
小型电喷雾萃取离子源的应用基础研究
  • 批准号:
    21005024
  • 项目类别:
    青年科学基金项目
  • 资助金额:
    19.0万元
  • 批准年份:
    2010
  • 负责人:
    李明
  • 依托单位: