Microengineered Bioactive Fibers for Fabrication of Vascularized Tissues

组织工程是一个多学科领域，汇集了工程，生物学，医学和化学背景的研究人员，以建立组织样结构，用于进行基础生物学研究和预测新的和现有药物的过敏或毒性潜力。随着生物制造技术的出现，如静电纺丝，光图案化和立体光刻，已经出现了令人兴奋的机会，用于创建可以为细胞生长和功能提供结构的支架。然而，对支架的机械性能、细胞分布和微结构的控制仍然是一个关键的挑战，特别是对于具有高度各向异性特性的组织，如心脏组织、骨骼肌和外周神经。

Tissue engineering is a multidisciplinary field that brings together researchers with backgrounds in engineering, biology, medicine, and chemistry to build tissue-like constructs for performing fundamental biological studies and predicting the allergenic or toxic potentials of novel and existing drugs. With the advent of biofabrication techniques such as electrospinning, photo patterning, and stereolithography, exciting opportunities have emerged for creating scaffolds that can provide a structure for the cells to grow and function. However, control over the mechanical properties, cellular distribution, and microarchitecture of the scaffolds still remains a critical challenge, especially for tissues with highly anisotropic properties such as cardiac tissue, skeletal muscles, and peripheral nerves.