Synthesis of Novel Sugar-Nucleic Acid Polymers

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Natural molecules like DNA and RNA are sugar-nucleic acid polymers that have desirable biological function.However, expanding the applications of sugar-nucleic acid polymers are needed for downstreambiotechnological applications because natural DNA and RNA are susceptible to degradation in the biologicalenvironment. Synthose is a company that specializes in the chemistry of sugars. Synthose has interests inexpanding their platform to nucleic acids. Based on the expertise of Synthose in sugar chemistry, and theexpertise in nucleic acid chemistry by Dr. Desaulniers' research group at the University of Ontario Institute ofTechnology (UOIT), new proposed sugar-nucleic acid polymers will be synthesized and studied. The workdescribed will foster a new collaboration between the UOIT and the chemical industry sector and will generateunique structures that may have interesting future commercial value. As such, the new knowledge gainedthrough the development of new sugar-nucleic acid polymers will offer exciting potential for the chemistry andbiotechnology fields.