Development of Nanobubbles and Glycoliposomes as Innovative Nanomaterials and Drug Delivery Platforms for Improving Hydrophobic Pharmaceutical Solubility in Water

许多有效的药物都是疏水性的，这意味着它们在水中不能很好地溶解，这使得它们能够与体内的酶和蛋白质很好地相互作用。关键结果技术公司(COT)在其药物流水线中有许多疏水药物，需要新型纳米材料药物输送平台来改善溶解性。COT正在与温莎大学的化学专家Trant实验室合作，开发全新类别的纳米材料，这种材料可以帮助稳定水溶液中的憎水化合物。合作者将考虑使用两种创新的纳米技术，纳米气泡、微小的氧气气泡和糖脂质体(表面有糖的纳米脂肪球，可以针对特定类型的细胞)作为这个老问题的新解决方案。这将意味着这些不同类型的药物将能够用于帮助加拿大人，合作伙伴预计这些策略将适用于各种不同的化合物。该项目将COTS在制药业务方面的专业知识和市场知识与UWindsor在化学和研究开发方面的专业知识结合在一起。预计这将导致为COTS制药管道开发新的药物输送平台，并帮助该公司扩大这部分业务，回收以前被搁置的活性良好但水溶性不足的药物。这一伙伴关系预计将创造一项新技术，同时还将在安大略省创造新的高质量研发工作岗位。

Many effective drugs are hydrophobic, meaning they do not dissolve well in water, this allows them to interact very well withenzymes and proteins in the body. Critical Outcome Technologies (COT) has a number of hydrophobic drugs in itspharamaceutical pipeline, and requires new types of nanomaterial drug delivery platforms to improve solubility. COT is teaming up with the Trant lab at the University of Windsor, experts in chemistry, at the University of Windsor to develop entirely new classes of nanomaterials that can help stabilize hydophobic compounds in water solutions. The collaborators will look at using two types of innovative nanotechnology, nanobubbles, tiny oxygen bubbles, and glycoliposomes (nano-sized fat globules with sugars on the surface that can target particular cell types) as new solutions to this old problem. This will mean that these different types of drugs will be able to be used to help Canadians, and the partners expect these strategies to be applicable to a wide variety of different compounds. This project brings together COTs expertise in the pharmaceutical business and knowledge of the market, with UWindsors expertise in chemistry and research development. It is expected to result in the development of new drug delivery platforms for COTs pharmaceutical pipeline and to help the company expand this part of their business in recovering previously shelved drugs that showed promising activity but insufficient water solubility. This partnership is expected to create a new technology while also leading to the creation of new high-quality research and development jobs in Ontario.