Protocol Development for Utilizing Bench-top NMR Spectrometers in an Inert Atmosphere Glove Box

核磁共振（NMR）光谱是化学家、生物化学家、生物学家和制药工业用来确定化学身份和结构的有力工具。尽管核磁共振波谱具有广泛的用途，但它是最后一种被淘汰的分析技术。Nanalysis Corp.是一家位于加拿大卡尔加里的小型公司，生产小型“台式”NMR光谱仪。尽管他们已经开发出了行业领先的技术，但他们还没有制定出在手套箱这种特殊环境中操作仪器的协议，手套箱是学术、工业和制药化学家使用的一种特殊工具，用于储存必须在惰性气氛下储存的空气敏感化学品。海斯在莱斯布里奇大学。Hayes是空气敏感化学和核磁共振光谱学方面的专家，拥有在手套箱内对台式核磁共振光谱仪进行操作测试所需的资源。通过这个项目获得的信息将使Nanalysis进入一个新的市场，从而扩大客户群，最终创造就业机会。重要的是要认识到，许多加拿大人使用的产品所涉及的许多化学品（例如用于制药的金属催化剂或用于制造塑料的烯烃）会与空气中的氧气和水分发生负面反应。因此，能够更快、更有效地完成这些工作的技术改进将使加拿大人受益，因为它降低了现有产品的成本，并导致新产品的更快开发。

Nuclear magnetic resonance (NMR) spectroscopy is a powerful tool used by chemists, biochemists, biologistsand the pharmaceutical industry to establish chemical identity and structure. Despite its broad utility, NMRspectroscopy was the last analytical technology to miniaturize. Nanalysis Corp. is a small, Calgary-basedCanadian company that manufactures small "bench-top" NMR spectrometers. Although they have developedindustry leading technology, they have not yet created protocols for operating their instruments in the unusualenvironment of a glove box, a special tool employed by academic, industrial and pharmaceutical chemists whouse air-sensitive chemicals that must be stored under an inert atmosphere.The proposed project involves a collaboration between Nanalysis Corp. and Prof. Paul G. Hayes at theUniversity of Lethbridge. Hayes is an expert in air-sensitive chemistry and NMR spectroscopy and possessesresources necessary to provide operational testing of a bench-top NMR spectrometer inside a functioning glovebox. The information obtained throughout this project will allow Nanalysis to access a new market, therebygrowing their customer base, ultimately leading to job creation. It is important to recognize that manychemicals relevant to products used by many Canadians (e.g. metal catalysts that are used to makepharmaceuticals or polymerize alkenes to make plastics) react negatively with oxygen and moisture in the air.Thus, technological improvements that enable such work to be completed more quickly and efficiently willbenefit Canadians by lowering the cost of existing products and leading to more rapid development of newones.