Ion Mobility Mass Spectrometer for Studying Protein Structure and Dynamics
Ion Mobility Mass Spectrometer for Studying Protein Structure and Dynamics
批准号:
RTI-2018-00388
负责人:
Konermann, Lars
金额:
$10.92万
依托单位国家:
加拿大
项目类别:
Research Tools and Instruments
财政年份:
2017
资助国家:
加拿大
项目状态:
已结题
起止时间:
2017-01-01 至 2018-12-31
中文摘要
我们要求迫切需要的离子迁移率质谱(IM/MS)仪器氢/氘交换(HDX)测量,将阐明蛋白质在健康和疾病中的作用。HDX技术对于探测蛋白质动力学至关重要。柔性片段经历快速HDX,而折叠区域中的氘化是缓慢的。这些信息是对X射线晶体学、低温电子显微镜和NMR光谱学数据的补充。HDX技术具有独特的优势,它们可以报告功能重要的蛋白质动力学
英文摘要
We request an urgently needed ion mobility mass spectrometry (IM/MS) instrument for hydrogen/deuterium exchange (HDX) measurements that will elucidate the role of proteins in health and disease. HDX techniques are essential for probing protein dynamics. Flexible segments undergo rapid HDX, while deuteration in folded regions is slow. This information is complementary to data from X-ray crystallography, cryo-electron microscopy, and NMR spectroscopy. HDX techniques have the unique advantage that they can report on functionally important protein dynamics
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Protein Structure and Dynamics Studied by Mass Spectrometry
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批准号:RGPIN-2018-04243
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项目类别:Discovery Grants Program - Individual
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资助金额:$8.81万
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财政年份:2022
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负责人:Konermann, Lars
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依托单位:
Protein Structure and Dynamics Studied by Mass Spectrometry
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批准号:RGPIN-2018-04243
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项目类别:Discovery Grants Program - Individual
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资助金额:$8.81万
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财政年份:2021
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负责人:Konermann, Lars
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依托单位:
Protein Structure and Dynamics Studied by Mass Spectrometry
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批准号:RGPIN-2018-04243
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项目类别:Discovery Grants Program - Individual
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资助金额:$8.81万
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财政年份:2020
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负责人:Konermann, Lars
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依托单位:
Protein Structure and Dynamics Studied by Mass Spectrometry
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批准号:RGPIN-2018-04243
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项目类别:Discovery Grants Program - Individual
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资助金额:$8.81万
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财政年份:2019
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负责人:Konermann, Lars
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依托单位:
Protein Structure and Dynamics Studied by Mass Spectrometry
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批准号:RGPIN-2018-04243
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项目类别:Discovery Grants Program - Individual
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资助金额:$8.81万
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财政年份:2018
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负责人:Konermann, Lars
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依托单位:
Protein Structure and Dynamics Studied by Mass Spectrometry
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批准号:217080-2013
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项目类别:Discovery Grants Program - Individual
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资助金额:$7.21万
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财政年份:2017
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负责人:Konermann, Lars
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依托单位:
Protein Structure and Dynamics Studied by Mass Spectrometry
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批准号:217080-2013
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项目类别:Discovery Grants Program - Individual
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资助金额:$7.21万
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财政年份:2015
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负责人:Konermann, Lars
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依托单位:
Protein Structure and Dynamics Studied by Mass Spectrometry
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批准号:217080-2013
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项目类别:Discovery Grants Program - Individual
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资助金额:$7.21万
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财政年份:2014
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负责人:Konermann, Lars
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依托单位:
Protein Structure and Dynamics Studied by Mass Spectrometry
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批准号:217080-2013
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项目类别:Discovery Grants Program - Individual
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资助金额:$7.21万
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财政年份:2013
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负责人:Konermann, Lars
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依托单位:
Canada Research Chair in Biophysical Protein Mass Spectrometry
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批准号:1000208025-2008
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项目类别:Canada Research Chairs
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资助金额:$5.46万
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财政年份:2013
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负责人:Konermann, Lars
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依托单位:
Folding and structural dynamics of proteins studied by electrospray mass spectrometry
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批准号:217080-2008
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项目类别:Discovery Grants Program - Individual
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资助金额:$5.1万
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财政年份:2012
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负责人:Konermann, Lars
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依托单位:
Canada Research Chair in Biophysical Protein Mass Spectrometry
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批准号:1000208025-2008
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项目类别:Canada Research Chairs
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资助金额:$7.29万
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财政年份:2012
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负责人:Konermann, Lars
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依托单位:
Folding and structural dynamics of proteins studied by electrospray mass spectrometry
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批准号:217080-2008
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项目类别:Discovery Grants Program - Individual
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资助金额:$5.1万
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财政年份:2011
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负责人:Konermann, Lars
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依托单位:
An Integrated System for Studying Protein Structure and Dynamics by Hydrogen Exchange Mass Spectrometry
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批准号:422442-2012
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项目类别:Research Tools and Instruments - Category 1 (<$150,000)
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资助金额:$10.92万
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财政年份:2011
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负责人:Konermann, Lars
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依托单位:
Canada Research Chair in Biophysical Protein Mass Spectrometry
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批准号:1000208025-2008
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项目类别:Canada Research Chairs
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资助金额:$7.29万
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财政年份:2011
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负责人:Konermann, Lars
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依托单位:
Folding and structural dynamics of proteins studied by electrospray mass spectrometry
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批准号:217080-2008
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项目类别:Discovery Grants Program - Individual
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资助金额:$5.1万
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财政年份:2010
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负责人:Konermann, Lars
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依托单位:
Folding and structural dynamics of proteins studied by electrospray mass spectrometry
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批准号:364526-2008
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项目类别:Discovery Grants Program - Accelerator Supplements
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资助金额:$2.91万
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财政年份:2010
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负责人:Konermann, Lars
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依托单位:
Canada Research Chair in Biophysical Protein Mass Spectrometry
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批准号:1000208025-2008
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项目类别:Canada Research Chairs
-
资助金额:$7.29万
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财政年份:2010
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负责人:Konermann, Lars
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依托单位:
Canada Research Chair in Biophysical Protein Mass Spectrometry
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批准号:1000208025-2008
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项目类别:Canada Research Chairs
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资助金额:$7.29万
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财政年份:2009
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负责人:Konermann, Lars
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依托单位:
Excimer laser for studying ultra-rapid protein folding events
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批准号:389893-2010
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项目类别:Research Tools and Instruments - Category 1 (<$150,000)
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资助金额:$5.41万
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财政年份:2009
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负责人:Konermann, Lars
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依托单位:
海外基金