Two photon imaging and optoporation or retinal cells
Two photon imaging and optoporation or retinal cells
批准号:
RTI-2018-00960
负责人:
Sarunic, Marinko
金额:
$10.93万
依托单位:
依托单位国家:
加拿大
项目类别:
Research Tools and Instruments
财政年份:
2017
资助国家:
加拿大
项目状态:
已结题
起止时间:
2017-01-01 至 2018-12-31
中文摘要
药物治疗可用于湿性年龄相关性黄斑变性(AMD),失明的主要原因。相比之下,对于许多其他不可逆的抢夺视力的疾病,如干性黄斑变性和青光眼,目前尚无有效的治疗方法。由于视网膜细胞位于眼睛的后部,治疗药物的输送受到阻碍。为了对视网膜进行治疗,必须克服眼睛的保护功能。纳米粒子是将治疗药物输送到视网膜的通用载体,但通常在所需的细胞层中吸收较低。
英文摘要
Pharmacological treatments are available for wet Age-related Macular Degeneration (AMD), a leading cause of blindness. In contrast, there is currently no effective treatment for many other irreversible vision robbing diseases, such as dry AMD and glaucoma. The delivery of therapeutic agents to the afflicted cells of the retina is hampered by their location at the back of the eye. In order to get treatments to the retina, the protective features of the eye must be overcome. Nanoparticles are versatile vehicles for delivery of therapeutics to the retina, but often have low uptake in the desired cell layers.
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会议论文
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项目类别:Discovery Grants Program - Individual
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资助金额:$3.42万
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