Boron Chemistry for Catalysis and Drug Discovery

有机硼化学，即研究含有碳-硼键的有机化合物，通过提供正在改变方式的化学反应，发挥着关键作用 合成药物是在制药业生产的。被提名者是硼酸基础研究和应用方面的专家， 一类方便的硼化合物，具有独特的性质，并可在适当的条件下发生反应。使用新的硼酸化学， 拟议计划的目标有两个：1)发明新的反应和新的催化剂，以实现或改善更环保的化学反应 (“更环保”)和更具成本效益，2)将这些发现转化为人类健康(即癌症)等领域的现实问题的解决方案 化疗药物)。这些挑战将通过开发新的碳-碳键形成反应来解决，以获得和优化 显示抗癌属性。

Organoboron chemistry, the study of organic compounds containing carbon-boron bonds, plays a key role by providing chemical reactions that are changing the way synthetic drugs are produced in the pharmaceutical industry. The nominee is an expert on fundamental research and applications of boronic acids, a stable and convenient class of boron compounds that display unique properties and can be turned reactive under the right conditions. Using novel chemistry of boronic acids, the goal of the proposed program is two-fold: 1) to invent new reactions and new catalysts to achieve or improve chemical reactions that are environmentally friendlier ("greener") and more cost-effective, 2) to translate these discoveries into solutions for real-life problems in areas such as human health (i.e., cancer chemotherapeutics). These challenges will be tackled by developing novel carbon-carbon bond forming reactions to access and optimize classes of molecules that display anticancer properties.