Simulation-based Scale-up of Bioreactors using Computational Multiphysics

生物反应器（生物反应器）的使用在生物生产中是普遍的，其中需要培养**种微生物来生产抗生素、疫苗和生物疗法。生物反应器中涉及的生物过程导致生物反应器的设计和放大提出了极端的挑战，因为它们涉及耦合的多相多物理场，包括质量传输、相间质量交换、生物反应、多相流体动力学和能量传输。因此，与传统大宗化工行业的大规模连续反应器相比，商业规模的生物反应器主要是物理规模相对较小的间歇式反应器。**改进生物反应器的工程设计过程，特别是放大和优化，是生物制造的关键**优先事项。扩大用于新开发的抗生素和疫苗的中试生物反应器的规模，除了以更低的成本增加产量外，还可以更快地将它们推向市场。在此背景下，本研究项目涉及用于疫苗生产的生物反应器的优化**和设计的计算研究。这将通过使用尖端的多相模型、数值方法和对这些概念的理解的专业知识来完成。

The use of bioreactors (biological reactors) is pervasive in biological manufacturing, where the cultivation of**microorganisms is required for the production of antibiotics, vaccines, and biological theraputics. The**biological processes involved in bioreactors results in the design and scale-up of bioreactors presenting extreme**challenges in that they involve coupled multiphase multiphysics including mass transport, interphase mass**exchange, biological reaction, multiphase hydrodynamics, and**energy transport. Consequently, commercial-scale bioreactors are mainly batch reactors with relatively small**physical scales, compared to large-scale continuous reactors in traditional bulk chemicals industry.**Improvements in engineering design processes for bioreactors, specifically scale-up and optimization, are key**priorities in biological manufacturing. Scale-up of pilot-scale bioreactors for newly developed antibiotics and**vaccines would result in more rapidly bringing them to market, in addition to production in increased quantities**at lower costs. Within this context, this research project involves computational research for the optimization**and design of bioreactors used for vaccine production. This will be accomplished through the use of**cutting-edge multiphase models, numerical methods, and specialized expertise in the understanding of these**concepts.