Design of new Asymmetric, Ion Pairing Catalysis and Reactions

* * 0 * 0 * 1 * 261 * 1554 * UofM * 23 * 1 * 1814 * 14.0 * * * * *** * 正常* 0 * * * * * 假*假*假* * en - us *是* X-NONE * * * * * * * * * * * * * * * * * * * * * * * * * ** * * * * * * * * * * * * * * * * * * * * * * * * * * * * * * * * * * * * * * * * * * * * * * * * * * * * * * * * * * * * * * * * * * * * * * * * * * * * * * * * * * * * * ** * * * * * * * * * * * * * * * * * * * * * * * * * * * * * * * * * * * * * * * * * * * * * * * * * * * **** /* 样式定义* / *表。MsoNormalTable* {mso-style-name:"Table Normal"；* mso-tstyle-rowband-size: 0;* mso-tstyle-colband-size: 0;* mso-style-noshow:是的;* mso-style-priority: 99;* mso-style-parent:“”;* mso-padding-alt:0cm 5.4pt；* mso-para-margin: 0厘米;* mso-para-margin-bottom: .0001pt;* mso-pagination: widow-orphan;*字体大小:12.0分;*字体类型:威尔士;* mso-ascii-font-family:威尔士;* mso-ascii-theme-font: minor-latin;* mso-hansi-font-family:威尔士;* mso-hansi-theme-font: minor-latin;* mso-ansi-language: en - us;****提议的研究计划*侧重于开发用于生产*手性有机化学品的不对称催化过程。手性化合物在制药和农化工业中发挥着重要作用。这些分子可以以镜像的形式存在（称为对映体），是所有生命的基石。众所周知，一种化合物的对映体可以具有截然不同的生物活性。开发强大而可靠的不对称催化过程以形成手性化合物的单一对映体是有机化学领域的一个持续挑战。不对称离子配对催化领域代表了一种非常有前途和通用的方法，用于产生广泛的复杂手性分子。虽然这一催化领域的发展迅速，但急于开发这些方法的潜力，在创新和理解之间留下了空白。深入了解这些催化剂的机制需要扩大反应库，可以用这种不对称催化方法进行。***提出的*发现研究将为这些不对称催化剂产生手性分子单个对映体的机制提供基本的见解。拟议的研究将扩大我们的对映选择性反应库，并引领普遍适用的工业相关催化方法的发展，这将允许形成以前无法实现的复杂手性分子。参与该研究项目的学生将培养动力学和计算化学的技能，以探索反应机理，并学习先进的合成和表征技术，这些技术将使他们因其广泛的技能组合而受到高度追捧

* * 0* 0* 1* 261* 1554* UofM* 23* 1* 1814* 14.0* * * * *** * Normal* 0* * * * * false* false* false* * EN-US* JA* X-NONE* * * * * * * * * * * * * * * * * * * * * * * * * ** * * * * * * * * * * * * * * * * * * * * * * * * * * * * * * * * * * * * * * * * * * * * * * * * * * * * * * * * * * * * * * * * * * * * * * * * * * * * * * * * * * * * * * * * * * * * * * * * * * * * * * * * * * * * * * * * * * * * * * * * * * * * * * * * * * * * * * * * * * **** /* Style Definitions */*table.MsoNormalTable* {mso-style-name:"Table Normal";* mso-tstyle-rowband-size:0;* mso-tstyle-colband-size:0;* mso-style-noshow:yes;* mso-style-priority:99;* mso-style-parent:"";* mso-padding-alt:0cm 5.4pt 0cm 5.4pt;* mso-para-margin:0cm;* mso-para-margin-bottom:.0001pt;* mso-pagination:widow-orphan;* font-size:12.0pt;* font-family:Cambria;* mso-ascii-font-family:Cambria;* mso-ascii-theme-font:minor-latin;* mso-hansi-font-family:Cambria;* mso-hansi-theme-font:minor-latin;* mso-ansi-language:EN-US;}****The proposed research program*focuses on the development of asymmetric catalytic processes for the production*of chiral organic chemicals. Chiral compounds play an important role in*pharmaceutical and agrochemical industries. These molecules, which can exist as*mirror images (called enantiomers), are the building blocks of all life. It is*well established that the enantiomers of a compound can have vastly different*biological activities. It is a continuous challenge in organic chemistry to develop*robust and reliable asymmetric catalytic process that allow for the formation*of single enantiomers of chiral compounds. The field of Asymmetric, Ion Pairing*Catalysis represents an extremely promising and versatile approach for*generating a wide range of complex chiral molecules. While development*in this area of catalysis has been rapid, the rush to exploit the potential of*these methods has left a void between innovation and understanding. An in-depth*knowledge of the mechanisms of these catalysts is required to expand the arsenal*of reactions that can be performed with this asymmetric catalytic method.***The proposed*discovery research will provide fundamental insight into the mechanisms*of these asymmetric catalysts in generating single enantiomers of chiral*molecules. The proposed research will expand our arsenal of enantioselective*reactions, and lead the development of generally applicable, industrially*relevant catalytic methods*that will allow for the formation of previously unachievable complex chiral*molecules. Students*involved in this research program will develop skills in kinetic and computational*chemistry for exploring reactions mechanism and learn advanced synthesis and*characterization techniques that together will make them highly sought after*for their broad skill set.***