NSERC CREATE Collaborative Medicinal Chemistry Network in Epigenetics Training (ChemNET):Training Canadian chemists within a global open access public-private partnership

拟议的CREATE计划（表观遗传学培训药物化学网络; ChemNET）将 ** 在开放获取的国际研究合作中培训下一代药物化学家，该合作涉及四所加拿大大学，结构基因组学联盟（SGC）-一个位于多伦多大学的非营利性研究组织，以及辉瑞，诺华和GSK的国际研究实验室。学员将产生研究工具，以研究表观遗传学，一个基本的基因调控机制，影响疾病，如癌症，抑郁症和糖尿病，以及生物能源，畜牧科学和农业。所产生的化学工具将提供给所有研究人员，不受使用限制，作为世界领先的开放获取科学运动的一部分。ChemNET学员将在加拿大各地的大学接受培训，但也将在制药公司的国际实验室中度过一段时间-全球药物化学热点。这个行业实习是至关重要的，因为药物化学是一门最好的学科“在工作中”学习。ChemNET还将在多伦多大学的SGC进行为期两个月的“训练营”，以补充化学培训，在那里，受训人员除了参加表观遗传学初级课程外，还将学习药物设计的专门生物化学和生物物理技术。年度研究研讨会将为学员提供机会，展示他们的工作，并与药物化学的学术和全球行业领导者建立联系。一个特别的在线研讨会课程将邀请一系列演讲者与受训者就与其培训有关的主题进行公开讨论。ChemNET的最终目标是通过发展他们的技术和理论知识以及他们的沟通，协作和组织技能，为学术界，工业界或政府监管部门培养高素质的药物化学家。这些科学家将领导加拿大未来在制药、农业和生物能源领域的表观遗传学工作。

The proposed CREATE program (Medicinal Chemistry Network in Epigenetics Training; ChemNET) will**train the next generation of medicinal chemists within an open access, international research collaboration involving four Canadian universities, the Structural Genomics Consortium (SGC) - a not-for-profit research organization based at the University of Toronto, and the international research labs of Pfizer, Novartis and GSK. The trainees will generate research tools to study the science of epigenetics, a fundamental gene regulatory mechanism that influences diseases such as cancer, depression and diabetes, as well as bioenergy, livestock science and agriculture. The chemical tools generated will be made available to all researchers without restriction on use, as part of a world-leading movement in open access science.****ChemNET trainees will train in universities across Canada, but will also spend time in the international labs of the pharmaceutical companies- the global hotspots for medicinal chemistry. This industry internship is critical because medicinal chemistry is a discipline best learned "on the job". ChemNET will also complement the chemistry training with a two-months "Bootcamp" at the SGC at the University of Toronto, where the trainees will learn specialized biochemical and biophysical techniques for drug design, in addition to enrolling in a primer course on epigenetics. An Annual Research Symposium will provide the trainees with the opportunity to present their work and network with academic and global industry leaders of medicinal chemistry. A special online seminar course will invite a range of speakers for an open discussion with the trainees on topics of relevance to their training. ChemNET's ultimate objective is to train highly-qualified medicinal chemists for academia, industry or the regulatory divisions of government by developing their technical and theoretical knowledge as well as their communication, collaborative and organizational skills. These scientists will lead Canada's future epigenetics efforts within the pharmaceutical, agriculture and bioenergy sectors.****