Synthesis of Novel Indole-Based Heterocycles

* * 0* 0* 1* 292* 1671* 尼皮辛大学 * 13* 3* 1960* 14.0* 正常 * 0* 假 * 假 ** 假 * * EN-US* JA* X-NONE* * * * * * * * * * * * * * * * * * * * * * * * * ***** * * * * * * * * * * * * * * * * * * * * * * * * * * * * * * * * * * * * * * * * * * * * * * * ** * * * * * * * * * * * * * * * * * * * * * * * * * * * * * * * * * * * * * * * * * * * * * * * * ** /* 样式定义 */* 表.MsoNormalTable* {mso-style-name：“表正常”;* mso-tstyle-rowband-size：0;* mso-tstyle-colband-size：0;* mso-style-noshow：是;* mso风格优先级：99;* mso-style-parent：“";* mso-padding-alt：0in 5.4pt 0in 5.4pt;* mso-para-margin：0in;* mso-para-margin-bottom：.0001pt;* mso-pagination：widow-orphan;* font-size：12.0pt;* font-family：Cambria;* mso-assign-font-family：Cambria;* mso-assign-theme-font：minor-latin;* mso-hansi-font-family：Cambria;* mso-hansi-theme-font：minor-latin;创造性有机合成是满足众多研究领域需求的基石（如制药、农用化学品、材料科学、催化、光化学、香料和颜料），其中不断寻找具有有趣性质和拓扑结构的新型分子框架。对于合成化学家来说，开发和微调反应方法，使所需骨架的高效和绿色合成成为可能至关重要。吲哚核是许多天然产物和生物活性化合物中普遍存在的亚结构。由于吲哚类化合物在生物学上的重要性，它作为药物化学家开发治疗药物的基础材料引起了特别的关注。围绕吲哚核心的大量生物活性继续成为开发新方法以发现有用化合物和增加杂环多样性的驱动力。因此，需要开发有效的 * 和实用的合成吲哚轴承各种取代模式 * 是非常重要的。我的研究计划的目标是探索 * 和发展新的和有效的合成方法吲哚杂环 * 轴承各种取代模式。长期目标是使用 * 开发的方法来丰富吲哚核周围的杂环多样性 *，以找到商业上有用的化学品。拟议的研究计划将导致新的吲哚为基础的 * 分子结构与有趣的生物学特性和3-D* 拓扑结构。这些分子也可以作为合成所需框架的化合物的结构单元。我们将特别注意 * 将绿色特性（如清洁和定量转化、* 温和条件、催化剂回收、原子经济性、一锅级联反应 * 和低废物产生）纳入我实验室开发的方法中，以提高其实用性和商业重要性。大约25-30名学生（HQP）将在赠款期限内接受培训。HQP接受的培训将使他们更好地为加拿大各地的工业，政府和大学实验室的研究活动做出贡献。********

* * 0* 0* 1* 292* 1671* Nipissing University* 13* 3* 1960* 14.0* * * * ***** * Normal* 0* * * * * false* false* false* * EN-US* JA* X-NONE* * * * * * * * * * * * * * * * * * * * * * * * * ***** * * * * * * * * * * * * * * * * * * * * * * * * * * * * * * * * * * * * * * * * * * * * * * * * * * * * * * * * * * * * * * * * * * * * * * * * * * * * * * * * * * * * * * * * * * * * * * * * * * * * * * * * * * * * * * * * * * * * * * * * * * * * * * * * * * * * * * * * * * ****** /* Style Definitions */*table.MsoNormalTable* {mso-style-name:"Table Normal";* mso-tstyle-rowband-size:0;* mso-tstyle-colband-size:0;* mso-style-noshow:yes;* mso-style-priority:99;* mso-style-parent:"";* mso-padding-alt:0in 5.4pt 0in 5.4pt;* mso-para-margin:0in;* mso-para-margin-bottom:.0001pt;* mso-pagination:widow-orphan;* font-size:12.0pt;* font-family:Cambria;* mso-ascii-font-family:Cambria;* mso-ascii-theme-font:minor-latin;* mso-hansi-font-family:Cambria;* mso-hansi-theme-font:minor-latin;}********Creative organic synthesis is a cornerstone for feeding the*demands of numerous research areas (such as pharmaceuticals, agrochemicals,*material sciences, catalysis, photochemistry, fragrances and pigments) where*novel molecular frameworks with interesting properties and topology are*constantly sought. It is crucial for synthetic chemists to develop and*fine-tune reaction methodologies that enable efficient and green synthesis of*the desired skeletons. The indole core is a prevalent substructure in many*natural products and biologically active compounds. Due to its biological*importance, indole based compounds attract special attention as a building*block for the development of therapeutic agents by medicinal chemists. A*plethora of bioactivities surrounding the indole-core continue to be a driving*force in the development of new methodology to find useful compounds and*increase the heterocyle diversity. Thus, the need for development of efficient*and practical syntheses of indoles bearing a variety of substitution patterns*is of great significance. The objective of my research program is to explore*and develop novel and efficient synthetic methodology of indole heterocycles*bearing a variety of substitution patterns. The long-term goal is to use the*developed methodology to enrich the heterocycle diversity around indole nucleus*to find commercially useful chemicals.***The proposed research program will lead to novel indole-based*molecular architectures with interesting biological properties and 3-D*topology. These molecules could also serve as building blocks for synthesizing*compounds of desired frameworks. Particular attention will be given to*incorporating green properties (such as, clean and quantitative conversion,*mild conditions, catalyst recycling, atom economy, one-pot cascade reactions,*and low waste production) to methodologies developed in my laboratory in*order to advance their practical and commercial importance. Approximately 25-30 students (HQP) will be trained over the tenure of the grant. The training received by HQPs will better prepare them to contribute to research activities in industry, government, and university laboratories across Canada. ********