Microalgae fermentation on C5 sugar from hemicellulose waste: Multi-omic analysis and modeling for rational bioprocess engineering

Mara Renewables Corporation是一家加拿大大西洋藻类生物产品生产商。该公司正**寻求扩大生产，以包括生物燃料，但目前受到碳源成本高昂的限制。该项目的目标是开发一种新陈代谢模型，以确定基因工程**战略，使该公司的微藻能够利用半纤维素--纸浆和造纸工业的副产品**，在新斯科舍省和加拿大更广泛地大量生产。半纤维素主要由五碳(C5)糖组成，微藻无法有效地处理这些糖。该项目将**专注于使用核磁共振(NMR)分析来确定C5糖的代谢作用，并**将这些数据整合到一个模型中，以确定如何通过基因工程提高C5的利用率。成功的结果将使Mara能够生产廉价和可持续的生物燃料，通过出口潜力和进一步的经济发展，使加拿大**消费者和加拿大工业受益。

Mara Renewables Corporation is an Atlantic Canadian producer of algal-based bio-products. The company is**seeking to expand its production to include biofuels, but it is currently limited by the high cost of carbon**sources. The goal of this project is to develop a metabolic model capable to identifying a genetic engineering**strategy that would enable the company's microalgae to use hemicellulose - a byproduct of the pulp and paper**industry, produced in large quantities in Nova Scotia and Canada more broadly. Hemicellulose is primarily**composed of five-carbon (C5) sugar, which the microalgae are not able to process effectively. The project will**focus on using nuclear magnetic resonance (NMR) analysis to identify the metabolic role of C5 sugar and**integrate this data into a model to determine how to increase C5 utilization through genetic engineering. A**successful outcome will enable Mara to produce cheap and sustainable biofuel, benefiting the Canadian**consumer and Canadian industry through export potential and further economic development.**