Microwave-enhanced synthesis of Au and Ag nanoparticles

SKNANO一直致力于研究和开发，原型，测试，创新的合成和制造的金和银纳米粒子，主要用于生物医学应用。对于制药和生物相关的应用，严格要求均匀的纳米颗粒，在尺寸和形状上都具有高度的可重复性。否则，它们在生物相关过程中的生物缀合和随后的性能可能会有很大不同，这在很大程度上增加了数据分析的复杂性，并引入了数据/性能不一致性。然而，实现高批次间重现性仍然具有挑战性，特别是对于超小、粗糙、高表面积的纳米颗粒。微波辅助合成，使用微波辐射直接向反应物提供快速和均匀的由内向外加热，可以提供比任何先前技术更精确的反应条件控制，并且代表了以非常高的再现性合成纳米颗粒的独特工具。这个短项目的主要目标是开发微波增强合成路线，以获得非常小的Au和Ag纳米颗粒的均匀，稳定的胶体溶液，具有高的批次间重现性。同时，我们也有兴趣建立配体之间的关系，纳米粒子在微波下的生长机制，表面化学，分散体中的胶体稳定性，这可以为未来的材料开发提供指导。

SKNANO has been dedicated to research and development, prototyping, testing, innovative synthesis and fabrication of gold and silver nanoparticles, mainly for biomedical applications. For pharmaceutical and bio-related applications, uniform nanoparticles, highly reproducible in both size and shape, are strictly required. Otherwise, their bio-conjugation and subsequent performance during bio-related processes can be quite different, largely increasing complicity of data analysis and introducing data/performance inconsistency. It is however still challenging to achieve high batch-to-batch reproducibility, especially for ultrasmall, rough, high-surface-area nanoparticles. Microwave-assisted synthesis, using microwave irradiation to provide rapid and uniform inside-out heating directly to reactants, can provide much more precise control over reaction conditions than any previous technology and represents a unique tool to synthesizing nanoparticles with very high reproducibility. The main goal of this short project is to develop microwave-enhanced synthesis routes in order to obtain uniform, stable colloidal solutions of very small Au and Ag NPs, with high batch-to-batch reproducibility. Meanwhile, we are also interested in establishing the relationship between ligands, nanoparticle growth mechanism under microwave, surface chemistry, and colloidal stability in dispersion, which can provide guides for future material development.