Understanding formulation characteristics on the glass transition of spray powders fortified with cannabis oils

在加拿大，大麻目前在娱乐市场上作为干燥的植物材料或通过油和溶液口服给药，以及奇怪的个人性润滑剂（Fleure de Lune：HEXO Corp）。虽然大麻通常是吸食的，但吸入燃烧过的干燥植物物质显然与固有的健康风险有关，即使是烟草的一小部分也是不可接受的。 难道我们没有从烟草业学到什么吗？口服给药消除了与吸入热解产品相关的肺部健康风险，并允许准确剂量的活性成分，如THC和CBD。不幸的是，由于大麻素的溶解度差和生物利用度非常低的药物，这些挑战阻碍了口服产品的市场增长。 我们打算研究含有大麻油的可流动粉末的设计。 将大麻油添加到粉末如麦芽糖糊精（通常是优异的玻璃态载体粉末）中会降低其玻璃化转变温度，导致最终粉末具有粘性和较差的流动性能，这将导致缺乏消费者接受度。 我们设计了一个三元相图来研究麦芽糊精-载体油-大麻油喷雾干燥粉末的流动性、粘度和玻璃化转变温度。 该信息的行业目标是允许Motif设计一种货架稳定的富含麦芽糊精大麻的成分，可能用于食用娱乐市场，或者可以进一步加工并压缩成医疗市场的表格（超出本Engage的范围）。

In Canada, cannabis currently is prescribed or sold on the recreational market as dried plant material or orally administered via oils and solutions, and oddly as personal sex lubricant (Fleure de Lune: HEXO Corp). While cannabis is typically smoked, inhalation of burned, dry plant matter is obviously associated with inherent health risks which are unacceptable even if at a fraction of tobacco. Have we learned nothing from the tobacco industry? Oral administration eliminates the pulmonary health risks associated with inhalation of pyrolyzed products and allows for accurate dosing of active ingredients such as THC and CBD. Unfortunately, challenges are impeding market growth of oral products due to cannabinoids poor solubility and dispersibility rendering products with very low bioavailability. We intend to study the design of flowable powders containing cannabis oil. Addition of cannabis oils to powders such as maltodextrin (typically an excellent glassy carrier powder) lower its glass transition temperature causing the final powered to be sticky with poor flow performance, which will lead to a lack of consumer acceptance. We have designed a ternary phase diagram to study the flowability, dispersibility, and glass transition temperatures of maltodextrin-carrier oil-cannabis oil spray dried powders. The industry objective of this information is to allow Motif to design a shelf-stable maltodextrin cannabis-enriched ingredient potentially for the edible recreational market or that can be further processed and compacted into tables for the medical market (beyond the scope of this Engage).