Boron Chemistry for Catalysis and Drug Discovery

有机硼化学是一门研究含有碳硼键的有机化合物的学科，它通过提供化学反应来改变制药行业合成药物的生产方式，发挥了关键作用。被提名人是硼酸基础研究和应用方面的专家，硼酸是一类稳定而方便的硼化合物，具有独特的性质，在适当的条件下可以转变为反应性。利用硼酸的新化学，该计划的目标是双重的：1)发明新的反应和新的催化剂，以实现或改善更环保（“绿色”）和更经济的化学反应，2)将这些发现转化为解决现实生活中存在的问题，如人类健康（即癌症化疗）。这些挑战将通过开发新的碳-碳键形成反应来解决，以获得和优化具有抗癌特性的分子类别。

Organoboron chemistry, the study of organic compounds containing carbon-boron bonds, plays a key role by providing chemical reactions that are changing the way synthetic drugs are produced in the pharmaceutical industry. The nominee is an expert on fundamental research and applications of boronic acids, a stable and convenient class of boron compounds that display unique properties and can be turned reactive under the right conditions. Using novel chemistry of boronic acids, the goal of the proposed program is two-fold: 1) to invent new reactions and new catalysts to achieve or improve chemical reactions that are environmentally friendlier ("greener") and more cost-effective, 2) to translate these discoveries into solutions for real-life problems in areas such as human health (i.e., cancer chemotherapeutics). These challenges will be tackled by developing novel carbon-carbon bond forming reactions to access and optimize classes of molecules that display anticancer properties.