Cell Stress and Inflammation

为了正常发挥功能，蛋白质必须折叠成正确的形状。有时蛋白质折叠不正确，错误折叠的蛋白质会累积。如果延长或扩大，就会导致细胞死亡。压力反应有助于降低错误折叠的蛋白质水平。最近的证据表明，压力反应也可以改变细胞间的通讯，但我们不知道是如何改变的。这个研究项目询问压力下的细胞如何与邻近的细胞交流并影响它们。这一知识将极大地增加我们对整个身体背景下的细胞应激反应的理解，而不是作为单个应激细胞中发生的孤立事件。

To function properly proteins must be folded into the correct shape. Sometimes protein folding does not occur correctly and misfolded proteins accumulate. If prolonged or extensive, this leads to cell death. Stress responses help lower the level of misfolded proteins. Recent evidence suggests stress responses can also alter cell-to-cell communication but we do not understand how. This research program asks how stressed cells communicate with and influence their neighbouring cells. This knowledge will greatly increase our understanding of cellular stress responses in the context of the body as a whole, and not as isolated events occurring in single, stressed cells.