Development of pH-responsive carriers for the controlled release of encapsulated acidifying and antibacterial agents.

随着抗药性微生物的幽灵和新出现的传染病隐约可见， 建立和保持严格和最新的消毒做法至关重要。 在越来越多的行业。除了有效中和病原体外，新型消毒剂 配方必须尽可能对环境无害，并且对接触这些物质的人无毒 物质。在卫生领域，氯长期以来作为一种直接的广谱物质得到了应用。 消毒剂。然而，某些微生物，包括隐孢子虫--最常见的致病因子 娱乐用水疾病--对氯处理具有抵抗力。要解决此问题，需要使用 开发新的消毒剂或改进现有方法的效率。为此，我们 建议开发以pH敏感脂质体为基础的消毒剂配方。脂质体(脂双层 囊泡)是可持续的、固有的生物相容结构，在输送中得到了广泛的应用 包括显著提高了将抗菌剂输送到 细菌。我们的系统将由包裹季铵和过氧乙酸的脂质体组成 一种消毒剂，在pH值发生变化后，会与微生物细胞发生不稳定和融合。使用 这种新型消毒剂输送系统可以应用于原液或作为表面处理 将代表着在使卫生行业的消毒做法与 当代挑战。

With the ever-present specter of drug-resistant microbes and emerging infectious diseases looming large, establishing and maintaining stringent and up-to-date disinfection practices has taken on paramount importance in a growing number of industries. In addition to effectively neutralizing pathogens, novel disinfectant formulations must be, as much as possible, environmentally benign and nontoxic to individuals handling these substances. In the sanitation field, chlorine has long found application as a straightforward broad-spectrum disinfectant. However, certain microbes including Cryptosporidium - the most prevalent causative agent in recreational water illnesses - are resistant to chlorine treatment. Addressing this issue requires either the development of novel disinfectants or refinement of the efficiency of existing approaches. To this end, we propose to develop disinfectant formulations based on pH-sensitive liposomes. Liposomes (lipid bilayer vesicles) are sustainable, inherently biocompatible structures that have found broad application in the delivery of encapsulated compounds, including significantly increased efficiency in the delivery of antimicrobials to bacteria. Our system will comprise liposomes encapsulating quaternary ammonium and peracetic acid disinfectants that will undergo destabilization and fusion with microbial cells following a change in pH. With the ability to be applied in the bulk solution or as a surface treatment, this novel disinfectant delivery system will represent a significant step forward in aligning disinfectant practices in the sanitation industry with contemporary challenges.