Alternative gel hand sanitizers and non-alcohol-based long-term sanitizers for surfaces and skin with anti-viral activity for COVID-19 response

在我们等待新冠肺炎的疫苗或有效治疗方法的同时，在当今的紧急危机中，手部和表面消毒剂仍将是必不可少的工具，而且在重返工作的现实中也将如此。新冠肺炎是一场全球性的流行病。这不仅意味着它威胁到全人类，还意味着它强调了我们全球化的供应链，这意味着洗手液的原材料变得很难获得。世卫组织的配方是一种出色的紧急解决方案，但这种液体配方在手上停留的时间不足以进行适当的消毒，而且如果长时间频繁使用，它也会对皮肤产生刺激性。需要更温和的配方，并且凝胶在手上停留至少20秒是首选的。然而，由于供应和需求压力，用于胶状消毒剂的标准成分不可用。此外，任何酒精洗手液，凝胶或液体，只有在其他清洁的手才真正有效：污垢或油脂的存在使其效果大大降低。 在温莎-埃塞克斯，温莎大学的Trant实验室联合了一批营利性公司，开发加拿大制造的解决方案。我们已经向急救人员和公众发放了数万升消毒剂。这笔赠款支持我们过渡到设计1)使用现成成分的新凝胶配方；2)即使在肮脏的双手上也有效的无水、油基配方，以确保基本工作人员在社区工作时仍能保持安全；3)长效安全的液体消毒剂，将确保经常接触的表面保持无COVID，并最大限度地减少维护。我们的消毒剂正在对细菌、老鼠冠状病毒和SARS-CoV-2进行筛选。以Wolfhead Distillery和Peak Processing为代表的工业团队一直在协助遵守法规，扩大到1000升批次，包装、分销，并可能将这些配方商业化，以确保我们的新有效配方将尽快进入公众手中。

While we await vaccines or effective treatments for COVID-19, hand and surface sanitizers are going to remain essential tools in the emergency crisis today, and in the return-to work reality. COVID-19 is a global pandemic. This not only means that it threatens all of humanity; it also means that it has stressed our globalized supply chains, meaning that the raw ingredients for hand sanitizers have become difficult to obtain. The WHO formula is an excellent emergency solution, but the liquid formulation does not remain on the hands long enough to properly disinfect, and it is also harsh on the skin when used frequently for a prolonged period. A gentler formulation is required, and gels that remain on the hands for at least 20 seconds are preferred. The standard ingredients used for gelling sanitizers, however, are not available because of both the supply and demand pressures. Furthermore, any alcohol hand sanitizer, gel or liquid, is only truly effective on otherwise clean hands: the presence of dirt or grease render it far less effective. In Windsor-Essex, the Trant Lab at the University of Windsor has come together a group of for-profit companies to develop made-in-Canada solutions. We have already disbursed tens of thousands of litres of sanitizer to emergency workers and the public. This grant supports our transition to designing 1) new gelling formulations using readily available ingredients; 2) water-free, oil-based formulations that will be effective even on dirty hands to ensure that essential workers can remain safe while doing their work out in the community; and 3) long lasting and safe liquid disinfectants that will ensure that commonly touched surfaces remain COVID-free with minimal maintenance. Our sanitizers are being screened against bacteria and both a rat coronavirus and SARS-CoV-2. The industrial team, represented by Wolfhead Distillery and Peak Processing on this grant, have been assisting with regulatory compliance, scale-up to thousand litre batches, packaging, distribution, and possible commercialization of these formulations to make sure that our new effective recipes will get into the hands of the public as quickly as feasible.