Trafficking and folding of the hERG ion channel: implications for long QT syndrome type 2
Trafficking and folding of the hERG ion channel: implications for long QT syndrome type 2
批准号:
449632
负责人:
Read John
金额:
$1.27万
依托单位:
依托单位国家:
加拿大
项目类别:
Studentship Programs
财政年份:
2020
资助国家:
加拿大
项目状态:
已结题
起止时间:
2020-12-01 至 2021-12-01
中文摘要
心血管疾病是世界范围内的头号死因。hERG/Kv11.1离子通道功能障碍可导致2型长QT综合征(LQT 2),增加心律失常和心脏骤停的风险,在1/2500的白人中存在。
英文摘要
Cardiovascular disease is the number one cause of death worldwide. Dysfunction of the hERG/Kv11.1 ion channel is responsible for long QT syndrome type 2 (LQT2), which increases the risk of arrhythmia and cardiac arrest and is present in 1/2500 Caucasians.
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