Point-of-care COVID-19 sensor for rapid, large-scale testing

在这项研究中，我们打算开发一种经济、可重复、可靠、高精度的生物传感器，用于新冠肺炎诊断性“照顾点”测试。与SARS或MERS相比，无症状感染者的快速传播使新冠肺炎成为一种如此广泛和致命的流行病。依赖“社会疏远”措施会带来巨大的经济和社会代价；这种遵守不是可持续的长期解决方案。在研制出疫苗并在全球部署之前，必须进行准确的、大规模的负担得起的测试。就像家庭怀孕测试一样，拟议的便携式“看护点”设备将使用样本(如唾液)立即产生高度准确的结果。它将消除目前用于检测的传统的基于聚合酶链式反应的检测方法/协议所经历的时间延迟、高成本和瓶颈。建议的生物传感器将使用气溶胶喷射式3D打印机打印，并且可以在保持质量的情况下经济地进行缩放。该传感器可以快速部署在工作场所、学校、医院、机场等，以获得即时测试结果。 有机晶体管可以很好地作为生物传感器，因为它们可以在水介质中使用，并且表现出高灵敏度。这些设备被功能化，以检测COVID病毒。该设备将对新冠肺炎病毒进行快速检测，并使用患者的唾液进行检测。该设备将是一次性使用的设备，经过测试后可以安全处置。该设备将加快测试时间，还可以执行的测试数量，这是一天的要求。

In this study, we intend to develop an economical, repeatable, reliable, highly accurate biosensor for COVID-19 diagnostic "point-of-care" testing. The rapid transmission from asymptomatic infected people has made COVID-19 such a widespread and deadly pandemic compared to SARS or MERS. Relying on "social-distancing" measures comes at enormous economic and social cost; this type of compliance is not a sustainable long-term solution. Accurate, large-scale affordable testing is imperative until a vaccine is developed and deployed globally. Much like home pregnancy tests, the proposed portable "point-of-care" devices will use a sample (e.g. saliva) to generate immediate and highly accurate results. It will remove the time delays, high costs and bottle necks experienced with the traditional PCR-based testing methods/protocols currently being used for testing. The proposed biosensors will be printed using aerosol jet 3D printer and can economically be scaled while maintaining the quality. The sensor can be deployed quickly at workplaces, schools, hospitals, airports, etc. for immediate test results. Organic transistors work well as biosensors because they can be used in aqueous medium and also demonstrate high sensitivity. These devices are functionalized to detect COVID virus. This device will give a quick measurement of the COVID-19 virus and will use the patient saliva for testing. The device will be a single use disposable one that can be disposed safely after testing. This device will expedite the testing time and also the number of tests that can be performed which is the requirement of the day.