Selective Catalytic Hydrogenation and Functionalization of Polyenes

这项研究合作的目标是开发新的化学工艺，并了解原料小分子如何通过催化转化为高价值产品。目标是三个具有实际和根本重要性的不同转变。每一个目标都对均相催化中的已知方法提出了挑战。所寻求的产物很容易发生无数的副反应(过度还原、多聚加成、异构化)，因此必须通过量身定制的反应条件和过渡金属催化剂来实现高水平的动力学选择性。这些工艺的成功开发应该会导致在可持续化学制造中得到更广泛的应用。我们计划对单个过程采取类似的方法，包括最初广泛筛选反应条件和催化剂以发现“击中”条件，然后进行更仔细的反应优化和催化剂结构-反应性研究，最后展示过程的可扩展性和通用性。

The goal of this research collaboration is to develop new chemical processes and to understand how feedstock small molecules can be converted into high value products by catalysis. Three distinct transformations of practical and fundamental importance are targeted. Each target poses a challenge to known methods in homogenous catalysis. The products sought to be made can readily undergo a myriad of side-reactions (over reduction, poly addition, isomerization), thus a high level of kinetic selectivity must be achieved by tailored reaction conditions and transition metal catalysts. The successful development of these processes should lead to more broad applications in sustainable chemical manufacturing. We plan a similar approach to the individual processes, consisting of initial broad screening of reaction conditions and catalysts to discover "hit" conditions followed by more careful reaction optimization and catalyst structure-reactivity studies, and finally demonstration of process scalability and generality.