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Characterizing the non-redundant roles for histone modifying enzymes in stem cell-mediated muscle repair.

Characterizing the non-redundant roles for histone modifying enzymes in stem cell-mediated muscle repair.
表征组蛋白修饰酶在干细胞介导的肌肉修复中的非冗余作用。
批准号:
451759
负责人:
Dilworth F J
金额:
$68.55万
依托单位国家:
加拿大
项目类别:
Operating Grants
财政年份:
2021
资助国家:
加拿大
项目状态:
未结题
起止时间:
2021-09-01 至 2026-09-01

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中文摘要
翻译
该研究项目使用遗传小鼠模型来了解表观遗传酶如何调节肌肉干细胞的决定,以维持其作为干细胞的状态,或转化为肌肉细胞以修复受损的肌肉纤维。我们
英文摘要
This research project that uses genetic mouse models to understand how epigenetic enzymes regulate the decision made by muscle stem cells to either maintain their status as a stem cell, or convert into a muscle cell to repair a damaged muscle fibre. We ha
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Role for defective enhancer commissioning in the hypotonia phenotype of Kabuki Syndrome patients
  • 批准号:
    461314
  • 项目类别:
    Operating Grants
  • 资助金额:
    $68.27万
  • 财政年份:
    2022
  • 负责人:
    Dilworth F J
  • 依托单位:
Epigenetic changes affecting muscle stem cell function in the aging population
  • 批准号:
    382342
  • 项目类别:
    Operating Grants
  • 资助金额:
    $109.11万
  • 财政年份:
    2018
  • 负责人:
    Dilworth F J
  • 依托单位:
Epigenetic Regulation of Muscle Regeneration in Health and Disease
  • 批准号:
    312742
  • 项目类别:
    Operating Grants
  • 资助金额:
    $168.56万
  • 财政年份:
    2014
  • 负责人:
    Dilworth F J
  • 依托单位:
Epigenetic regulation of muscle gene expression during muscle regeneration
  • 批准号:
    303458
  • 项目类别:
    Operating Grants
  • 资助金额:
    $60.77万
  • 财政年份:
    2014
  • 负责人:
    Dilworth F J
  • 依托单位:
海外基金